{"doi":"10.1002/art.42368","title":"Reliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working Group","abstract":"OBJECTIVE: To assess the reliability and diagnostic accuracy of new radiographic imaging definitions developed by an international multidisciplinary working group for identification of calcium pyrophosphate deposition (CPPD). METHODS: Patients with knee osteoarthritis scheduled for knee replacement were enrolled. Two radiologists and 2 rheumatologists twice assessed radiographic images for presence or absence of CPPD in menisci, hyaline cartilage, tendons, joint capsule, or synovial membrane, using the new definitions. In case of disagreement, a consensus decision was made and considered for the assessment of diagnostic performance. Histologic examination of postsurgical specimens under compensated polarized light microscopy was the reference standard. Prevalence-adjusted bias-adjusted kappa values were used to assess reliability, and diagnostic performance statistics were calculated. RESULTS: Sixty-seven patients were enrolled for the reliability study. The interobserver reliability was substantial in most of the assessed structures when considering all 4 readers (κ range 0.59-0.90), substantial to almost perfect among radiologists (κ range 0.70-0.91), and moderate to almost perfect among rheumatologists (κ range 0.46-0.88). The intraobserver reliability was substantial to almost perfect for all the observers (κ range 0.70-1). Fifty-one patients were included in the accuracy study. Radiography demonstrated an overall specificity of 92% for CPPD, but sensitivity remained low for all sites and for the overall diagnosis (54%). CONCLUSION: The new radiographic definitions of CPPD are highly specific against the gold standard of histologic diagnosis. When the described radiographic findings are present, these definitions allow for a definitive diagnosis of CPPD, rather than other calcium-containing crystal depositions; however, a negative radiographic finding does not exclude the diagnosis.","journal":"Arthritis & Rheumatology","year":2022,"id":240777,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.892,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":703957,"name":"Fabio Becce","orcid":"0000-0001-8444-8504","position":1,"is_corresponding":false},{"id":868881,"name":"Luca Maria Sconfienza","orcid":"0000-0003-0759-8431","position":2,"is_corresponding":false},{"id":801853,"name":"Lene Terslev","orcid":"0000-0001-8193-9471","position":3,"is_corresponding":false},{"id":868882,"name":"Esperanza Naredo","orcid":"0000-0003-0017-0096","position":4,"is_corresponding":false},{"id":868883,"name":"Pascal Zufferey","orcid":"0000-0002-5067-3743","position":5,"is_corresponding":false},{"id":868884,"name":"Carlos Pineda","orcid":"0000-0003-0544-7461","position":6,"is_corresponding":false},{"id":868885,"name":"Marwin Gutiérrez","orcid":"0000-0002-7995-1110","position":7,"is_corresponding":false},{"id":868886,"name":"Antonella Adinolfi","orcid":"0000-0002-4034-7186","position":8,"is_corresponding":false},{"id":868887,"name":"Teodora Şerban","orcid":"0000-0002-8101-2833","position":9,"is_corresponding":false},{"id":869403,"name":"Daryl MacCarter","orcid":null,"position":10,"is_corresponding":false},{"id":868888,"name":"Gaël Mouterde","orcid":"0000-0002-0651-5035","position":11,"is_corresponding":false},{"id":868889,"name":"Anna Zanetti","orcid":"0000-0001-8408-451X","position":12,"is_corresponding":false},{"id":868890,"name":"Anna Scanu","orcid":"0000-0001-6497-5374","position":13,"is_corresponding":false},{"id":868891,"name":"Ingrid Möller","orcid":"0000-0002-9225-2568","position":14,"is_corresponding":false},{"id":869404,"name":"Ulrike Novo‐Rivas","orcid":null,"position":15,"is_corresponding":false},{"id":868892,"name":"Raquel Largo","orcid":"0000-0001-6525-2944","position":16,"is_corresponding":false},{"id":282331,"name":"Piercarlo Sarzi‐Puttini","orcid":"0000-0002-8673-5133","position":17,"is_corresponding":false},{"id":406255,"name":"Abhishek Abhishek","orcid":"0000-0003-0121-4919","position":18,"is_corresponding":false},{"id":236763,"name":"Hyon K. Choi","orcid":"0000-0002-2862-0442","position":19,"is_corresponding":false},{"id":258556,"name":"Nicola Dalbeth","orcid":"0000-0003-4632-4476","position":20,"is_corresponding":false},{"id":703954,"name":"Tristan Pascart","orcid":"0000-0002-8395-826X","position":21,"is_corresponding":false},{"id":335237,"name":"Sara K. 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