{"doi":"10.1002/art.42325","title":"2022 American College of Rheumatology/EULAR Classification Criteria for Giant Cell Arteritis","abstract":"OBJECTIVE: To develop and validate updated classification criteria for giant cell arteritis (GCA). METHODS: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate items, 2) prospective collection of candidate items present at the time of diagnosis, 3) expert panel review of cases, 4) data-driven reduction of candidate items, 5) derivation of a points-based risk classification score in a development data set, and 6) validation in an independent data set. RESULTS: The development data set consisted of 518 cases of GCA and 536 comparators. The validation data set consisted of 238 cases of GCA and 213 comparators. Age ≥50 years at diagnosis was an absolute requirement for classification. The final criteria items and weights were as follows: positive temporal artery biopsy or temporal artery halo sign on ultrasound (+5); erythrocyte sedimentation rate ≥50 mm/hour or C-reactive protein ≥10 mg/liter (+3); sudden visual loss (+3); morning stiffness in shoulders or neck, jaw or tongue claudication, new temporal headache, scalp tenderness, temporal artery abnormality on vascular examination, bilateral axillary involvement on imaging, and fluorodeoxyglucose-positron emission tomography activity throughout the aorta (+2 each). A patient could be classified as having GCA with a cumulative score of ≥6 points. When these criteria were tested in the validation data set, the model area under the curve was 0.91 (95% confidence interval [95% CI] 0.88-0.94) with a sensitivity of 87.0% (95% CI 82.0-91.0%) and specificity of 94.8% (95% CI 91.0-97.4%). CONCLUSION: The 2022 American College of Rheumatology/EULAR GCA classification criteria are now validated for use in clinical research.","journal":"Arthritis & Rheumatology","year":2022,"id":232449,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":199,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5357,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":5958,"name":"Peter C. Grayson","orcid":"0000-0002-8269-9438","position":1,"is_corresponding":false},{"id":385147,"name":"Joanna Robson","orcid":"0000-0002-7939-5978","position":2,"is_corresponding":false},{"id":385148,"name":"Ravi Suppiah","orcid":"0009-0009-1559-4896","position":3,"is_corresponding":false},{"id":330121,"name":"Katherine Gribbons","orcid":null,"position":4,"is_corresponding":false},{"id":361232,"name":"Andrew Judge","orcid":"0000-0003-3015-0432","position":5,"is_corresponding":false},{"id":385149,"name":"Anthea Craven","orcid":"0000-0001-9477-7889","position":6,"is_corresponding":false},{"id":842540,"name":"Sara Khalid","orcid":"0000-0002-2845-5731","position":7,"is_corresponding":false},{"id":842541,"name":"Andrew Hutchings","orcid":"0000-0003-0215-9923","position":8,"is_corresponding":false},{"id":25217,"name":"Richard A. Watts","orcid":"0000-0002-2846-4769","position":9,"is_corresponding":false},{"id":5969,"name":"Peter A. Merkel","orcid":"0000-0001-9284-7345","position":10,"is_corresponding":false},{"id":25207,"name":"Raashid Luqmani","orcid":"0000-0002-4446-5841","position":11,"is_corresponding":false},{"id":843302,"name":"for the DCVAS Study Group","orcid":null,"position":12,"is_corresponding":false},{"id":385146,"name":"Cristina Ponte","orcid":"0000-0002-3989-1192","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T00:21:12.348693Z","pmid":"36350123","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}