{"doi":"10.1002/art.42324","title":"2022 American College of Rheumatology/EULAR Classification Criteria for Takayasu Arteritis","abstract":"OBJECTIVE: To develop and validate new classification criteria for Takayasu arteritis (TAK). METHODS: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate criteria items, 2) collection of candidate items present at diagnosis, 3) expert panel review of cases, 4) data-driven reduction of candidate items, 5) derivation of a points-based classification score in a development data set, and 6) validation in an independent data set. RESULTS: The development data set consisted of 316 cases of TAK and 323 comparators. The validation data set consisted of an additional 146 cases of TAK and 127 comparators. Age ≤60 years at diagnosis and imaging evidence of large-vessel vasculitis were absolute requirements to classify a patient as having TAK. The final criteria items and weights were as follows: female sex (+1), angina (+2), limb claudication (+2), arterial bruit (+2), reduced upper extremity pulse (+2), reduced pulse or tenderness of a carotid artery (+2), blood pressure difference between arms of ≥20 mm Hg (+1), number of affected arterial territories (+1 to +3), paired artery involvement (+1), and abdominal aorta plus renal or mesenteric involvement (+3). A patient could be classified as having TAK with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the model area under the curve was 0.97 (95% confidence interval [95% CI] 0.94-0.99) with a sensitivity of 93.8% (95% CI 88.6-97.1%) and specificity of 99.2% (95% CI 96.7-100.0%). CONCLUSION: The 2022 American College of Rheumatology/EULAR classification criteria for TAK are now validated for use in research.","journal":"Arthritis & Rheumatology","year":2022,"id":234332,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8745,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":385146,"name":"Cristina Ponte","orcid":"0000-0002-3989-1192","position":1,"is_corresponding":false},{"id":385148,"name":"Ravi Suppiah","orcid":"0009-0009-1559-4896","position":2,"is_corresponding":false},{"id":385147,"name":"Joanna Robson","orcid":"0000-0002-7939-5978","position":3,"is_corresponding":false},{"id":330121,"name":"Katherine Gribbons","orcid":null,"position":4,"is_corresponding":false},{"id":361232,"name":"Andrew Judge","orcid":"0000-0003-3015-0432","position":5,"is_corresponding":false},{"id":385149,"name":"Anthea Craven","orcid":"0000-0001-9477-7889","position":6,"is_corresponding":false},{"id":842540,"name":"Sara Khalid","orcid":"0000-0002-2845-5731","position":7,"is_corresponding":false},{"id":842541,"name":"Andrew Hutchings","orcid":"0000-0003-0215-9923","position":8,"is_corresponding":false},{"id":289444,"name":"Debashish Danda","orcid":"0000-0002-2121-0942","position":9,"is_corresponding":false},{"id":25207,"name":"Raashid Luqmani","orcid":"0000-0002-4446-5841","position":10,"is_corresponding":false},{"id":25217,"name":"Richard A. Watts","orcid":"0000-0002-2846-4769","position":11,"is_corresponding":false},{"id":5969,"name":"Peter A. Merkel","orcid":"0000-0001-9284-7345","position":12,"is_corresponding":false},{"id":843302,"name":"for the DCVAS Study Group","orcid":null,"position":13,"is_corresponding":false},{"id":5958,"name":"Peter C. Grayson","orcid":"0000-0002-8269-9438","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T00:21:36.529874Z","pmid":"36349501","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}