{"doi":"10.1002/art.42162","title":"A Risk Score to Detect Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease","abstract":"OBJECTIVE: Patients at high risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) would benefit from being identified before the onset of respiratory symptoms; this can be done by screening patients with the use of chest high-resolution computed tomography (HRCT). Our objective was to develop and validate a risk score for patients who have subclinical RA-ILD. METHODS: Our study included a discovery population and a replication population from 2 prospective RA cohorts (ESPOIR and TRANSLATE2, respectively) without pulmonary symptoms who had received chest HRCT scans. All patients were genotyped for MUC5B rs35705950. After multiple logistic regression, a risk score based on independent risk factors for subclinical RA-ILD was developed in the discovery population and tested for validation in the replication population. RESULTS: The discovery population included 163 patients with RA, and the replication population included 89 patients with RA. The prevalence of subclinical RA-ILD was 19.0% and 16.9%, respectively. In the discovery population, independent risk factors for subclinical RA-ILD were presence of the MUC5B rs35705950 T allele (odds ratio [OR] 3.74 [95% confidence interval (95% CI) 1.37, 10.39]), male sex (OR 3.93 [95% CI 1.40, 11.39]), older age at RA onset (for each year, OR 1.10 [95% CI 1.04, 1.16]), and increased mean Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (for each unit, OR 2.03 [95% CI 1.24, 3.42]). We developed and validated a derived risk score with receiver operating characteristic areas under the curve of 0.82 (95% CI 0.70-0.94) for the discovery population and 0.78 (95% CI 0.65-0.92) for the replication population. Excluding MUC5B rs35705950 from the model provided a lower goodness of fit (likelihood ratio test, P = 0.01). CONCLUSION: We developed and validated a risk score that could help identify patients at high risk of subclinical RA-ILD. Our findings support an important contribution of MUC5B rs35705950 to subclinical RA-ILD risk.","journal":"Arthritis & Rheumatology","year":2022,"id":233844,"datarank":0.7130385286659547,"base_score":4.7535901911063645,"endowment":4.7535901911063645,"self_citation_contribution":0.7130385286659547,"citation_network_contribution":0.0,"self_endowment_contribution":0.7130385286659547,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":115,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9423,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":848282,"name":"Benjamin Granger","orcid":"0000-0002-1903-7212","position":1,"is_corresponding":false},{"id":848283,"name":"Marie‐Pierre Debray","orcid":"0000-0003-2109-5662","position":2,"is_corresponding":false},{"id":848284,"name":"Esther Ebstein","orcid":"0000-0002-5671-5473","position":3,"is_corresponding":false},{"id":848285,"name":"Fabienne Louis‐Sidney","orcid":"0000-0002-7378-5721","position":4,"is_corresponding":false},{"id":848286,"name":"Joanna Kedra","orcid":"0000-0003-3535-3183","position":5,"is_corresponding":false},{"id":275612,"name":"Tracy J. 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Sparks","orcid":"0000-0002-5556-4618","position":19,"is_corresponding":false},{"id":314628,"name":"Bruno Crestani","orcid":"0000-0002-2961-3455","position":20,"is_corresponding":false},{"id":773645,"name":"Bruno Fautrel","orcid":"0000-0001-8845-4274","position":21,"is_corresponding":false},{"id":801873,"name":"Philippe Dieudé","orcid":"0000-0002-4814-0307","position":22,"is_corresponding":false},{"id":848281,"name":"Pierre‐Antoine Juge","orcid":"0000-0002-3766-9600","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:21:31.237180Z","pmid":"35583934","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}