{"doi":"10.1002/ardp.200500984","title":"Chromatin Modifications as Targets for New Anticancer Drugs","abstract":"<jats:title>Abstract</jats:title><jats:p>Chromatin proteins undergo diverse posttranslational modifications, esp. acetylation and methylation, that contribute to the control of transcriptional processes. The result of these modifications in its various states is called the <jats:italic>histone code</jats:italic>. This review presents an overview of those modifications of chromatin proteins that affect the side chains of lysines and arginines and define variations of the chromatin acetylome and methylome. The relevant enzymes are presented and the feasibility to influence their activity by inhibition or activation is discussed. The manipulation of these enzymes is an exciting strategy towards an increased understanding of their role in the functionality of a cell. Additionally, this may lead to new approaches for the treatment of diseases that are based on a dysregu lation of transcription, especially cancer.</jats:p>","journal":"Archiv der Pharmazie","year":2005,"id":639147,"datarank":0.5806801516361837,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"self_citation_contribution":0.5806801516361837,"citation_network_contribution":0.0,"self_endowment_contribution":0.5806801516361837,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":29834,"name":"Manfred Jung","orcid":"0000-0002-6361-7716","position":1,"is_corresponding":false},{"id":1660464,"name":"Stefan Schäfer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chromatin Modifications as Targets for New Anticancer Drugs","abstract":"<jats:title>Abstract</jats:title><jats:p>Chromatin proteins undergo diverse posttranslational modifications, esp. acetylation and methylation, that contribute to the control of transcriptional processes. The result of these modifications in its various states is called the <jats:italic>histone code</jats:italic>. This review presents an overview of those modifications of chromatin proteins that affect the side chains of lysines and arginines and define variations of the chromatin acetylome and methylome. The relevant enzymes are presented and the feasibility to influence their activity by inhibition or activation is discussed. The manipulation of these enzymes is an exciting strategy towards an increased understanding of their role in the functionality of a cell. Additionally, this may lead to new approaches for the treatment of diseases that are based on a dysregu lation of transcription, especially cancer.</jats:p>","is_dataset_classified":null,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16041839","pmcid":null,"openalex_id":"https://openalex.org/W2096110071","authors":[],"funders":[],"total_grants":0,"fwci":2.3744,"citation_percentile":0.8845134,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fardp.200500984","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.200500984","host_type":"publisher"},{"url":"https://doi.org/10.1002/ardp.200500984","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16041839","host_type":"repository"},{"url":"https://freidok.uni-freiburg.de/data/59533","host_type":"repository"}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Cancer-related gene regulation","Protein Degradation and Inhibitors","Acetylation","Animals","Antineoplastic Agents","Chromatin","Histones","Humans","Protein Processing, Post-Translational"],"mesh_terms":["Acetylation","Animals","Antineoplastic Agents","Chromatin","Histones","Humans","Protein Processing, Post-Translational"],"keywords":["Chromatin","Acetylation","Histone","Epigenetics","Chromatin remodeling","Histone-modifying enzymes","Transcription (linguistics)","Methylation","Enzyme","Chemistry","Transcription factor","Computational biology","Cell biology","Biology","DNA","Biochemistry","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T22:40:24.888696Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}