{"doi":"10.1002/arch.940270205","title":"Isolation and characterization of a hemocyte aggregation inhibitor from hemolymph of <i>Manduca sexta</i> larvae","abstract":"<jats:title>Abstract</jats:title><jats:p>A protein that inhibits hemocyte aggregation has been isolated from hemolymph of <jats:italic>Manduca sexta</jats:italic> larvae and named hemocyte aggregation inhibitor protein (HAIP). HAIP has a M<jats:sub>r</jats:sub> = 50,000, pI = 8.5, and contains 7% carbohydrate. It is present at 230 ± 20 μg/ml in hemolymph of day 3 fifth instar larvae. Antibodies to HAIP do not cross‐react with <jats:italic>M. sexta</jats:italic> hemolin, which is similar in size and charge and also inhibits hemocyte aggregation. HAIP and hemolin have some similarity in amino acid composition and NH<jats:sub>2</jats:sub>‐terminal sequence, but are different in overall secondary structure, as determined by CD spectroscopy. The concentration of HAIP in hemolymph is not affected by injection of larvae with bacteria. A protein of approximately 50,000 daltons that reacts with antibody to <jats:italic>M. sexta</jats:italic> HAIP is present in hemolymph of <jats:italic>Bombyx mori, Heliothis zea</jats:italic>, and <jats:italic>Galleria mellonella</jats:italic>. Although the function of HAIP in vivo is not yet clear, it may have a role in modulating adhesion of hemocytes during defensive responses. © 1994 Wiley‐Liss, Inc.</jats:p>","journal":"Archives of Insect Biochemistry and Physiology","year":1994,"id":662443,"datarank":0.611630616585858,"base_score":4.07753744390572,"endowment":4.07753744390572,"self_citation_contribution":0.611630616585858,"citation_network_contribution":0.0,"self_endowment_contribution":0.611630616585858,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1729380,"name":"Melissa K. 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Antibodies to HAIP do not cross‐react with <jats:italic>M. sexta</jats:italic> hemolin, which is similar in size and charge and also inhibits hemocyte aggregation. HAIP and hemolin have some similarity in amino acid composition and NH<jats:sub>2</jats:sub>‐terminal sequence, but are different in overall secondary structure, as determined by CD spectroscopy. The concentration of HAIP in hemolymph is not affected by injection of larvae with bacteria. A protein of approximately 50,000 daltons that reacts with antibody to <jats:italic>M. sexta</jats:italic> HAIP is present in hemolymph of <jats:italic>Bombyx mori, Heliothis zea</jats:italic>, and <jats:italic>Galleria mellonella</jats:italic>. Although the function of HAIP in vivo is not yet clear, it may have a role in modulating adhesion of hemocytes during defensive responses. © 1994 Wiley‐Liss, Inc.</jats:p>","is_dataset_classified":null,"base_score":4.07753744390572,"endowment":4.07753744390572,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7949257","pmcid":null,"openalex_id":"https://openalex.org/W2153027472","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM041247","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI31084","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM41247","title":null}],"total_grants":3,"fwci":1.2624,"citation_percentile":0.80996566,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2024,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Farch.940270205","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/arch.940270205","host_type":"publisher"},{"url":"https://doi.org/10.1002/arch.940270205","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7949257","host_type":"repository"}],"fields_of_study":["Invertebrate Immune Response Mechanisms","Insect Resistance and Genetics","Silk-based biomaterials and applications"],"mesh_terms":["Amino Acid Sequence","Animals","Cell Adhesion","Chromatography, Gel","Circular Dichroism","Electrophoresis, Polyacrylamide Gel","Hemocytes","Hemolymph","Larva","Molecular Sequence Data","Proteins","Species Specificity","Sequence Alignment","Protein Structure, Secondary","Manduca"],"keywords":["Manduca sexta","Hemolymph","Biology","Sphingidae","Manduca","Galleria mellonella","Biochemistry","Lepidoptera genitalia","Instar","Bombyx mori","Insect","Larva","Microbiology","Botany"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12881031.v1","title":"Additional file 10 of The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12881031","title":"Additional file 10 of The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T14:59:39.053789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}