{"doi":"10.1002/ar.25059","title":"Impact of fetal treatments for congenital diaphragmatic hernia on lung development","abstract":"<jats:title>Abstract</jats:title><jats:p>The extent of lung hypoplasia impacts the survival and severity of morbidities associated with congenital diaphragmatic hernia (CDH). The alveoli of CDH infants and in experimental models of CDH have thickened septa with fewer type II pneumocytes and capillaries. Fetal treatments of CDH‐risk preterm birth. Therefore, treatments must aim to balance the need for increased gas exchange surface area with the restoration of pulmonary epithelial type II cells and the long‐term respiratory and neurodevelopmental consequences of prematurity. Achievement of sufficient lung development in utero for successful postnatal transition requires adequate intra‐thoracic space for lung growth, maintenance of sufficient volume and appropriate composition of fetal lung fluid, regular fetal breathing movements, appropriate gas exchange area, and ample surfactant production. The review aims to examine the rationale for current and future therapeutic strategies to improve postnatal outcomes of infants with CDH.</jats:p>","journal":"The Anatomical Record","year":2025,"id":624405,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1440502,"name":"Anna Lavizzari","orcid":"0000-0001-5529-0787","position":1,"is_corresponding":false},{"id":1614138,"name":"Jonathan W. 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Therefore, treatments must aim to balance the need for increased gas exchange surface area with the restoration of pulmonary epithelial type II cells and the long‐term respiratory and neurodevelopmental consequences of prematurity. Achievement of sufficient lung development in utero for successful postnatal transition requires adequate intra‐thoracic space for lung growth, maintenance of sufficient volume and appropriate composition of fetal lung fluid, regular fetal breathing movements, appropriate gas exchange area, and ample surfactant production. The review aims to examine the rationale for current and future therapeutic strategies to improve postnatal outcomes of infants with CDH.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36065499","pmcid":null,"openalex_id":"https://openalex.org/W4294751189","authors":[],"funders":[{"funder_name":"National Health and Medical Research Council","grant_id":"1196188","title":"Reducing global mortality and severity of disease in newborn infants through innovation and holistic interventions"},{"funder_name":"Metropolitan Health Research Infrastructure Fund","grant_id":"","title":null},{"funder_name":"Telethon Perth Children's Hospital Research Fund","grant_id":"","title":null}],"total_grants":3,"fwci":0.4202,"citation_percentile":0.61353729,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.25059","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.25059","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ar.25059","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ar.25059","host_type":"publisher"},{"url":"https://anatomypubs.onlinelibrary.wiley.com/doi/pdf/10.1002/ar.25059","host_type":"publisher"},{"url":"https://doi.org/10.1002/ar.25059","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36065499","host_type":"repository"},{"url":"https://research-repository.uwa.edu.au/en/publications/ff3ed3e7-0fed-40da-b86e-cb910e748998","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11889483","host_type":"repository"},{"url":"http://hdl.handle.net/11311/1220531","host_type":"repository"},{"url":"http://dx.doi.org/10.1002/ar.25059","host_type":""},{"url":"https://hdl.handle.net/11311/1220531","host_type":""}],"fields_of_study":["Congenital Diaphragmatic Hernia Studies","Neonatal Respiratory Health Research","Congenital Anomalies and Fetal Surgery","03 medical and health sciences","0302 clinical medicine","Hernias, Diaphragmatic, Congenital","Humans","Lung","Fetal Therapies","Animals","Infant, Newborn","Pregnancy"],"mesh_terms":["Animals","Female","Humans","Infant, Newborn","Lung","Pregnancy","Fetal Therapies","Hernias, Diaphragmatic, Congenital"],"keywords":["Congenital diaphragmatic hernia","Medicine","Lung","Fetus","In utero","Pulmonary hypoplasia","Hypoplasia","Diaphragmatic breathing","Lung volumes","Internal medicine","Pathology","Pregnancy","Biology","Fetal Therapies","fetal research","Infant, Newborn","Special Issue Article","lung hypoplasia","Humans","Animals","Hernias, Diaphragmatic, Congenital","alveolar development"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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