{"doi":"10.1002/anie.202420485","title":"Accessing Azetidines through Magnesium‐Mediated Nitrogen Group Transfer from Iminoiodinane to Donor‐Acceptor Cyclopropanes","abstract":"Herein, we report a Lewis acid-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. This protocol operates under mild, transition-metal-free conditions, and showcases excellent chemoselectivity, along with broad functional group tolerance. We report for the first time that challenging alkyl donor-acceptor cyclopropanes can undergo ring expansion leading to aliphatic azetidines without relying on external oxidants or precious transition-metal catalysts. Mechanistically, the coordination of a magnesium (Mg)-Lewis acid to the DAC promotes nucleophilic ring opening with a putative Mg-amide species generated from the iminoiodinane under the reaction conditions to furnish the azetidine products.","journal":"Angewandte Chemie International Edition","year":2025,"id":515445,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9425,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1356251,"name":"Lifeng Yin","orcid":null,"position":1,"is_corresponding":false},{"id":1379763,"name":"Ning Deng","orcid":"0009-0006-8559-147X","position":2,"is_corresponding":false},{"id":1355926,"name":"Mahmoud Afrasi","orcid":"0000-0002-5492-3869","position":3,"is_corresponding":false},{"id":1355927,"name":"Yiyi Zhu","orcid":"0009-0003-7173-0115","position":4,"is_corresponding":false},{"id":1099670,"name":"Marvin Parasram","orcid":"0000-0002-6052-0417","position":5,"is_corresponding":false},{"id":1179453,"name":"Ajay H. Bansode","orcid":"0009-0005-5489-872X","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:48:39.436300Z","pmid":"39776232","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}