{"doi":"10.1002/anie.202317565","title":"DNAzyme‐Catalyzed Site‐Specific N‐Acylation of DNA Oligonucleotide Nucleobases","abstract":"We used in vitro selection to identify DNAzymes that acylate the exocyclic nucleobase amines of cytidine, guanosine, and adenosine in DNA oligonucleotides. The acyl donor was the 2,3,5,6-tetrafluorophenyl ester (TFPE) of a 5'-carboxyl oligonucleotide. Yields are as high as >95 % in 6 h. Several of the N-acylation DNAzymes are catalytically active with RNA rather than DNA oligonucleotide substrates, and eight of nine DNAzymes for modifying C are site-specific (>95 %) for one particular substrate nucleotide. These findings expand the catalytic ability of DNA to include site-specific N-acylation of oligonucleotide nucleobases. Future efforts will investigate the DNA and RNA substrate sequence generality of DNAzymes for oligonucleotide nucleobase N-acylation, toward a universal approach for site-specific oligonucleotide modification.","journal":"Angewandte Chemie International Edition","year":2023,"id":340497,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1075009,"name":"Caroline K. Kaminsky","orcid":"0000-0001-8049-7499","position":1,"is_corresponding":false},{"id":1075010,"name":"Maria A. Massa","orcid":"0000-0002-3483-7955","position":2,"is_corresponding":false},{"id":1075558,"name":"Prakriti K. Das","orcid":null,"position":3,"is_corresponding":false},{"id":1075011,"name":"Robert D. Boyd","orcid":"0000-0003-1118-6296","position":4,"is_corresponding":false},{"id":1075559,"name":"Michelle Bishka","orcid":null,"position":5,"is_corresponding":false},{"id":1075012,"name":"J. Tomas Tricarico","orcid":"0009-0005-0539-1543","position":6,"is_corresponding":false},{"id":589662,"name":"Scott Silverman","orcid":"0000-0001-8166-3460","position":7,"is_corresponding":false},{"id":1075008,"name":"Morgan M. Kennebeck","orcid":"0000-0001-7342-9631","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:10:54.145367Z","pmid":"38157448","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}