{"doi":"10.1002/anie.202311099","title":"Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration","abstract":"Mononuclear nonheme iron(II) and 2-oxoglutarate (Fe/2OG)-dependent oxygenases and halogenases are known to catalyze a diverse set of oxidative reactions, including hydroxylation, halogenation, epoxidation, and desaturation in primary metabolism and natural product maturation. However, their use in abiotic transformations has mainly been limited to C-H oxidation. Herein, we show that various enzymes of this family, when reconstituted with Fe(II) or Fe(III), can catalyze Mukaiyama hydration-a redox neutral transformation. Distinct from the native reactions of the Fe/2OG enzymes, wherein oxygen atom transfer (OAT) catalyzed by an iron-oxo species is involved, this nonnative transformation proceeds through a hydrogen atom transfer (HAT) pathway in a 2OG-independent manner. Additionally, in contrast to conventional inorganic catalysts, wherein a dinuclear iron species is responsible for HAT, the Fe/2OG enzymes exploit a mononuclear iron center to support this reaction. Collectively, our work demonstrates that Fe/2OG enzymes have utility in catalysis beyond the current scope of catalytic oxidation.","journal":"Angewandte Chemie International Edition","year":2023,"id":328994,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":752176,"name":"Yong Lu","orcid":"0000-0002-3656-3185","position":1,"is_corresponding":false},{"id":918127,"name":"Lide Cha","orcid":null,"position":2,"is_corresponding":false},{"id":917761,"name":"Tzu‐Yu Chen","orcid":"0000-0002-5919-1556","position":3,"is_corresponding":false},{"id":1051524,"name":"Philip M. Palacios","orcid":null,"position":4,"is_corresponding":false},{"id":1051037,"name":"Liping Li","orcid":"0000-0002-6732-4902","position":5,"is_corresponding":false},{"id":777300,"name":"Yisong Guo","orcid":"0000-0002-4132-3565","position":6,"is_corresponding":false},{"id":681656,"name":"Wei‐chen Chang","orcid":"0000-0002-2341-9846","position":7,"is_corresponding":false},{"id":7766,"name":"Chuo Chen","orcid":"0000-0002-3118-4901","position":8,"is_corresponding":false},{"id":1051036,"name":"Bingnan Wang","orcid":"0000-0001-6714-5499","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:08:56.940647Z","pmid":"37639670","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}