{"doi":"10.1002/anie.202308292","title":"Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)","abstract":"Chemical probes are essential tools for understanding biological systems and for credentialing potential biomedical targets. Programmed cell death 2 (PDCD2) is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins, which are critical regulators of apoptosis. Here we report the discovery and characterization of 10 e, a first-in-class small molecule degrader of PDCD2. We discovered this PDCD2 degrader by serendipity using a chemical proteomics approach, in contrast to the conventional approach for making bivalent degraders starting from a known binding ligand targeting the protein of interest. Using 10 e as a pharmacological probe, we demonstrate that PDCD2 functions as a critical regulator of cell growth by modulating the progression of the cell cycle in T lymphoblasts. Our work provides a useful pharmacological probe for investigating PDCD2 function and highlights the use of chemical proteomics to discover selective small molecule degraders of unanticipated targets.","journal":"Angewandte Chemie International Edition","year":2023,"id":367359,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1025172,"name":"Woong Sub Byun","orcid":"0000-0003-4676-3698","position":1,"is_corresponding":false},{"id":33142,"name":"Wenchao Lu","orcid":"0000-0003-1175-365X","position":2,"is_corresponding":false},{"id":909583,"name":"Xijun Zhu","orcid":null,"position":3,"is_corresponding":false},{"id":299772,"name":"Katherine A. Donovan","orcid":"0000-0002-8539-5106","position":4,"is_corresponding":false},{"id":577164,"name":"Brendan G. Dwyer","orcid":"0000-0001-8593-4184","position":5,"is_corresponding":false},{"id":243062,"name":"Jianwei Che","orcid":"0000-0003-4956-4811","position":6,"is_corresponding":false},{"id":1124511,"name":"Linjie Yuan","orcid":"0000-0002-5641-6684","position":7,"is_corresponding":false},{"id":941558,"name":"Xianmixinuer Abulaiti","orcid":null,"position":8,"is_corresponding":false},{"id":3731,"name":"Steven M. Corsello","orcid":"0000-0002-9929-3709","position":9,"is_corresponding":false},{"id":262829,"name":"Eric S. Fischer","orcid":"0000-0001-7337-6306","position":10,"is_corresponding":false},{"id":226576,"name":"Tinghu Zhang","orcid":"0000-0003-1028-8020","position":11,"is_corresponding":false},{"id":226581,"name":"Nathanael S. Gray","orcid":"0000-0001-5354-7403","position":12,"is_corresponding":false},{"id":941557,"name":"Wenzhi Ji","orcid":null,"position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:15:12.215513Z","pmid":"37658265","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}