{"doi":"10.1002/anie.202305810","title":"Asymmetric Hydrative Aldol Reaction (HAR) via Vinyl‐Gold Promoted Intermolecular Ynamide Addition to Aldehydes","abstract":"Abstract Herein, we reported an intermolecular asymmetric hydrative aldol reaction through vinyl‐gold intermediate under ambient conditions. This tandem alkyne hydration and sequential nucleophilic addition afforded a “base‐free” approach to β‐hydroxy amides with high efficiency (up to 95 % yields, >50 examples). Vinyl gold intermediate was applied as reactive nucleophile and Fe(acac) 3 was used as the critical co‐catalyst to prevent undesired protodeauration, allowing this transformation to proceed under mild conditions with good functional group tolerance and excellent stereoselectivity (>20 : 1 d.r. and up to 99 % ee).","journal":"Angewandte Chemie International Edition","year":2023,"id":359458,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9402,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1110401,"name":"Kelton Radefeld","orcid":null,"position":1,"is_corresponding":false},{"id":385704,"name":"Chuan Shan","orcid":"0000-0002-5173-1335","position":2,"is_corresponding":false},{"id":1110402,"name":"Carter Wegner","orcid":null,"position":3,"is_corresponding":false},{"id":960212,"name":"Erin Nichols","orcid":"0000-0002-4917-1412","position":4,"is_corresponding":false},{"id":267205,"name":"Xiaohan Ye","orcid":"0000-0002-3836-4120","position":5,"is_corresponding":false},{"id":934958,"name":"Qi Tang","orcid":"0009-0004-7166-7854","position":6,"is_corresponding":false},{"id":369272,"name":"Łukasz Wojtas","orcid":"0000-0003-0545-0302","position":7,"is_corresponding":false},{"id":267206,"name":"Xiaodong Shi","orcid":"0000-0002-3189-1315","position":8,"is_corresponding":false},{"id":469585,"name":"Teng Yuan","orcid":"0009-0005-1568-6492","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"37276357","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}