{"doi":"10.1002/anie.202305568","title":"Methane Carboxylation Using Electrochemically Activated Carbon Dioxide","abstract":"Abstract Direct synthesis of CH 3 COOH from CH 4 and CO 2 is an appealing approach for the utilization of two potent greenhouse gases that are notoriously difficult to activate. In this Communication , we report an integrated route to enable this reaction. Recognizing the thermodynamic stability of CO 2 , our strategy sought to first activate CO 2 to produce CO (through electrochemical CO 2 reduction) and O 2 (through water oxidation), followed by oxidative CH 4 carbonylation catalyzed by Rh single atom catalysts supported on zeolite. The net result was CH 4 carboxylation with 100 % atom economy. CH 3 COOH was obtained at a high selectivity (>80 %) and good yield ( ca . 3.2 mmol g −1 cat in 3 h). Isotope labelling experiments confirmed that CH 3 COOH is produced through the coupling of CH 4 and CO 2 . This work represents the first successful integration of CO/O 2 production with oxidative carbonylation reaction. The result is expected to inspire more carboxylation reactions utilizing preactivated CO 2 that take advantage of both products from the reduction and oxidation processes, thus achieving high atom efficiency in the synthesis.","journal":"Angewandte Chemie International Edition","year":2023,"id":333838,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1061660,"name":"Yuhan Zhang","orcid":"0000-0003-4054-2552","position":1,"is_corresponding":false},{"id":1061661,"name":"Haoyi Li","orcid":"0000-0002-0723-8068","position":2,"is_corresponding":false},{"id":1061662,"name":"Muchun Fei","orcid":"0009-0006-0340-0562","position":3,"is_corresponding":false},{"id":1061663,"name":"Hongna Zhang","orcid":"0000-0002-4372-7707","position":4,"is_corresponding":false},{"id":1062244,"name":"John Santoro","orcid":null,"position":5,"is_corresponding":false},{"id":866381,"name":"Dunwei Wang","orcid":"0000-0001-5581-8799","position":6,"is_corresponding":false},{"id":1061659,"name":"Yucheng Yuan","orcid":"0000-0003-3935-0967","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:09:44.297718Z","pmid":"37141443","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}