{"doi":"10.1002/anie.202304796","title":"Copper‐Catalyzed Asymmetric Acylboration of 1,3‐Butadienylboronate with Acyl Fluorides","abstract":"We report herein a Cu-catalyzed regio-, diastereo- and enantioselective acylboration of 1,3-butadienylboronate with acyl fluorides. Under the developed conditions, the reactions provide (Z)-β,γ-unsaturated ketones bearing an α-tertiary stereocenter with high Z-selectivity and excellent enantioselectivities. While direct access to highly enantioenriched E-isomers was not successful, we showed that such molecules can be synthesized with excellent E-selectivity and optical purities via Pd-catalyzed alkene isomerization from the corresponding Z-isomers. The orthogonal chemical reactivities of the functional groups embedded in the ketone products allow for diverse chemoselective transformations, which provides a valuable platform for further derivatization.","journal":"Angewandte Chemie International Edition","year":2023,"id":335610,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9441,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045183,"name":"Jiaming Liu","orcid":"0000-0003-1327-0643","position":1,"is_corresponding":false},{"id":1065502,"name":"Diego Troya","orcid":"0000-0003-4971-4998","position":2,"is_corresponding":false},{"id":1045186,"name":"Ming Chen","orcid":"0000-0002-9841-8274","position":3,"is_corresponding":false},{"id":1045184,"name":"Shang Gao","orcid":"0000-0001-8166-5503","position":0,"is_corresponding":true}],"reference_count":109,"raw_metadata":null,"created_at":"2026-07-19T01:10:02.777338Z","pmid":"37712934","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}