{"doi":"10.1002/anie.202304013","title":"Enantioselective Hydroalkenylation and Hydroalkynylation of Alkenes Enabled by a Transient Directing Group: Catalyst Generality through Rigidification**","abstract":"The catalytic enantioselective synthesis of α-chiral alkenes and alkynes represents a powerful strategy for rapid generation of molecular complexity. Herein, we report a transient directing group (TDG) strategy to facilitate site-selective palladium-catalyzed reductive Heck-type hydroalkenylation and hydroalkynylation of alkenylaldehyes using alkenyl and alkynyl bromides, respectively, allowing for construction of a stereocenter at the δ-position with respect to the aldehyde. Computational studies reveal the dual beneficial roles of rigid TDGs, such as L-tert-leucine, in promoting TDG binding and inducing high levels of enantioselectivity in alkene insertion with a variety of migrating groups.","journal":"Angewandte Chemie International Edition","year":2023,"id":331055,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1055469,"name":"Turki M. Alturaifi","orcid":"0000-0002-6379-1669","position":1,"is_corresponding":false},{"id":786029,"name":"Johny M. Nguyen","orcid":"0000-0001-7044-9127","position":2,"is_corresponding":false},{"id":816516,"name":"Lucas J. Oxtoby","orcid":null,"position":3,"is_corresponding":false},{"id":1004679,"name":"Quynh Nguyen Wong","orcid":null,"position":4,"is_corresponding":false},{"id":321506,"name":"Jason S. Chen","orcid":"0000-0002-7341-5763","position":5,"is_corresponding":false},{"id":285942,"name":"Peng Liu","orcid":"0000-0002-8188-632X","position":6,"is_corresponding":false},{"id":315493,"name":"Keary M. Engle","orcid":"0000-0003-2767-6556","position":7,"is_corresponding":false},{"id":757495,"name":"Amit Kumar Simlandy","orcid":"0000-0002-8792-4825","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T01:09:14.691473Z","pmid":"37141510","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}