{"doi":"10.1002/anie.202219181","title":"Development of Dissolution Dynamic Nuclear Polarization of [<sup>15</sup>N<sub>3</sub>]Metronidazole: A Clinically Approved Antibiotic","abstract":"Abstract We report dissolution Dynamic Nuclear Polarization (d‐DNP) of [ 15 N 3 ]metronidazole ([ 15 N 3 ]MNZ) for the first time. Metronidazole is a clinically approved antibiotic, which can be potentially employed as a hypoxia‐sensing molecular probe using 15 N hyperpolarized (HP) nucleus. The DNP process is very efficient for [ 15 N 3 ]MNZ with an exponential build‐up constant of 13.8 min using trityl radical. After dissolution and sample transfer to a nearby 4.7 T Magnetic Resonance Imaging scanner, HP [ 15 N 3 ]MNZ lasted remarkably long with T 1 values up to 343 s and 15 N polarizations up to 6.4 %. A time series of HP [ 15 N 3 ]MNZ images was acquired in vitro using a steady state free precession sequence on the 15 NO 2 peak. The signal lasted over 13 min with notably long T 2 of 20.5 s. HP [ 15 N 3 ]MNZ was injected in the tail vein of a healthy rat, and dynamic spectroscopy was performed over the rat brain. The in vivo HP 15 N signals persisted over 70 s, demonstrating an unprecedented opportunity for in vivo studies.","journal":"Angewandte Chemie International Edition","year":2023,"id":341139,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1076655,"name":"Sameer M. Joshi","orcid":"0000-0001-8989-5661","position":1,"is_corresponding":false},{"id":1077191,"name":"Anna Samoilenko","orcid":null,"position":2,"is_corresponding":false},{"id":1076656,"name":"Mohammad Shah Hafez Kabir","orcid":"0000-0003-4952-8730","position":3,"is_corresponding":false},{"id":896736,"name":"Erin Hardy","orcid":null,"position":4,"is_corresponding":false},{"id":1077192,"name":"Atsush M. Takahashi","orcid":null,"position":5,"is_corresponding":false},{"id":746879,"name":"Jan Henrik Ardenkjær‐Larsen","orcid":"0000-0001-6167-6926","position":6,"is_corresponding":false},{"id":402028,"name":"Eduard Y. Chekmenev","orcid":"0000-0002-8745-8801","position":7,"is_corresponding":false},{"id":730305,"name":"Yi‐Fen Yen","orcid":"0000-0001-9986-5327","position":8,"is_corresponding":false},{"id":1028166,"name":"David Guarin","orcid":"0000-0002-1388-0559","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:11:03.393978Z","pmid":"37247411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}