{"doi":"10.1002/anie.202217814","title":"Two‐Dimensional Supramolecular Polymerization of DNA Amphiphiles is Driven by Sequence‐Dependent DNA‐Chromophore Interactions","abstract":"Two-dimensional (2D) assemblies of water-soluble block copolymers have been limited by a dearth of systematic studies that relate polymer structure to pathway mechanism and supramolecular morphology. Here, we employ sequence-defined triblock DNA amphiphiles for the supramolecular polymerization of free-standing DNA nanosheets in water. Our systematic modulation of amphiphile sequence shows the alkyl chain core forming a cell membrane-like structure and the distal π-stacking chromophore block folding back to interact with the hydrophilic DNA block on the nanosheet surface. This interaction is crucial to sheet formation, marked by a chiral \"signature\", and sensitive to DNA sequence, where nanosheets form with a mixed sequence, but not with a homogeneous poly(thymine) sequence. This work opens the possibility of forming well-ordered, bilayer-like assemblies using a single DNA amphiphile for applications in cell sensing, nucleic acid therapeutic delivery and enzyme arrays.","journal":"Angewandte Chemie International Edition","year":2023,"id":333166,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":514363,"name":"Jacob M. Remington","orcid":null,"position":1,"is_corresponding":false},{"id":876111,"name":"Finley Clark","orcid":"0000-0002-0435-6448","position":2,"is_corresponding":false},{"id":1060999,"name":"Haochen Bai","orcid":null,"position":3,"is_corresponding":false},{"id":1060404,"name":"Violeta Toader","orcid":"0000-0001-8291-177X","position":4,"is_corresponding":false},{"id":1061000,"name":"Dmytro F. Perepichka","orcid":null,"position":5,"is_corresponding":false},{"id":268860,"name":"Jianing Li","orcid":"0000-0002-0143-8894","position":6,"is_corresponding":false},{"id":282460,"name":"Hanadi F. Sleiman","orcid":"0000-0002-5100-0532","position":7,"is_corresponding":false},{"id":1060403,"name":"Muhammad Ghufran Rafique","orcid":"0000-0003-4394-184X","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"36939824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}