{"doi":"10.1002/anie.202214786","title":"Ruthenium‐Catalyzed Butadiene‐Mediated Crotylation and Oxazaborolidine‐Catalyzed Vinylogous Mukaiyama Aldol Reaction for The Synthesis of C1–C19 and C23–C35 of Neaumycin B","abstract":"Neaumycin B is a femtomolar inhibitor of U87 human glioblastoma. Using a newly developed anti-diastereoselective ruthenium-catalyzed butadiene-mediated crotylation of primary alcohol proelectrophiles via hydrogen auto-transfer, as well as a novel variant of the catalytic asymmetric vinylogous Mukaiyama aldol (VMA) reaction applicable to linear aliphatic aldehydes and terminally methylated dienyl ketene acetals, preparation of the key C1-C19 and C23-C35 substructures of neaumycin B is achieved in 12 and 7 steps (LLS), respectively.","journal":"Angewandte Chemie International Edition","year":2022,"id":259216,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9441,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":795872,"name":"Minjin Yoo","orcid":null,"position":1,"is_corresponding":false},{"id":911918,"name":"Tabitha T. Schempp","orcid":null,"position":2,"is_corresponding":false},{"id":911384,"name":"Saki Maejima","orcid":"0009-0002-8043-1064","position":3,"is_corresponding":false},{"id":596116,"name":"Michael J. Krische","orcid":"0000-0001-8418-9709","position":4,"is_corresponding":false},{"id":911917,"name":"Xinting Liang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T00:25:47.305414Z","pmid":"36322115","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}