{"doi":"10.1002/anie.202214086","title":"Turning on the Antimicrobial Activity of Gold Nanoclusters Against Multidrug‐Resistant Bacteria**","abstract":"Abstract In this work, we show that the addition of thiourea (TU) initiated broad‐spectrum antimicrobial activity of otherwise inactive D‐maltose‐capped gold nanoclusters (AuNC‐Mal). For example, AuNC‐Mal/TU was effective against multidrug‐resistant Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 1 μg mL −1 (2.5 μM [Au]) while having 30–60 times lower in vitro cytotoxicity against mammalian cells. The reaction of AuNC‐Mal and TU generated the antimicrobial species of [Au(TU) 2 ] + and smaller AuNCs. TU increased the accumulation of Au in bacteria and helped maintain the oxidation state as Au I (vs. Au III ). The modes of action included the inhibition of thioredoxin reductase, interference with the Cu I regulation and depletion of ATP. Moreover, the antimicrobial activity did not change in the presence of colistin or carbonyl cyanide 3‐chlorophenylhydrazone, suggesting that AuNC‐Mal/TU was indifferent to the outer membrane barrier and to bacterial efflux pumps.","journal":"Angewandte Chemie International Edition","year":2023,"id":331597,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":580731,"name":"Dang Truong","orcid":null,"position":1,"is_corresponding":false},{"id":675717,"name":"N. G. Hasitha Raviranga","orcid":"0000-0002-0002-6126","position":2,"is_corresponding":false},{"id":676303,"name":"Jingzhe Lao","orcid":null,"position":3,"is_corresponding":false},{"id":675718,"name":"Olof Ramström","orcid":"0000-0002-1533-6514","position":4,"is_corresponding":false},{"id":463185,"name":"Mingdi Yan","orcid":"0000-0003-1121-4007","position":5,"is_corresponding":false},{"id":675716,"name":"William Ndugire","orcid":"0000-0001-7818-4274","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T01:09:25.015646Z","pmid":"36642692","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}