{"doi":"10.1002/anie.202209730","title":"Expedient Synthesis of a Library of Heparan Sulfate‐Like “Head‐to‐Tail” Linked Multimers for Structure and Activity Relationship Studies**","abstract":"Heparan sulfate (HS) plays important roles in many biological processes. The inherent complexity of naturally existing HS has severely hindered the thorough understanding of their structure-activity relationship. To facilitate biological studies, a new strategy has been developed to synthesize a HS-like pseudo-hexasaccharide library, where HS disaccharides were linked in a \"head-to-tail\" fashion from the reducing end of a disaccharide module to the non-reducing end of a neighboring module. Combinatorial syntheses of 27 HS-like pseudo-hexasaccharides were achieved. This new class of compounds bound with fibroblast growth factor 2 (FGF-2) with similar structure-activity trends as HS oligosaccharides bearing native glycosyl linkages. The ease of synthesis and the ability to mirror natural HS activity trends suggest that the new head-to-tail linked pseudo-oligosaccharides could be an exciting tool to facilitate the understanding of HS biology.","journal":"Angewandte Chemie International Edition","year":2022,"id":255775,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9434,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":174879,"name":"Li Liang","orcid":null,"position":1,"is_corresponding":false},{"id":490925,"name":"Weizhun Yang","orcid":"0000-0001-5522-4026","position":2,"is_corresponding":false},{"id":490927,"name":"Sherif Ramadan","orcid":"0000-0002-8639-4105","position":3,"is_corresponding":false},{"id":890942,"name":"Kedar N. Baryal","orcid":null,"position":4,"is_corresponding":false},{"id":890943,"name":"Chang‐Xin Huo","orcid":null,"position":5,"is_corresponding":false},{"id":417740,"name":"Jamie J. Bernard","orcid":"0000-0002-3800-2576","position":6,"is_corresponding":false},{"id":288986,"name":"Jian Liu","orcid":"0000-0001-8552-1400","position":7,"is_corresponding":false},{"id":363255,"name":"Linda C. Hsieh‐Wilson","orcid":"0000-0001-5661-1714","position":8,"is_corresponding":false},{"id":233177,"name":"Fuming Zhang","orcid":"0000-0003-2803-3704","position":9,"is_corresponding":false},{"id":286697,"name":"Robert J. Linhardt","orcid":"0000-0003-2219-5833","position":10,"is_corresponding":false},{"id":308597,"name":"Xuefei Huang","orcid":"0000-0002-6468-5526","position":11,"is_corresponding":false},{"id":483361,"name":"Jicheng Zhang","orcid":"0000-0001-8797-2053","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T00:25:17.224217Z","pmid":"36199167","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}