{"doi":"10.1002/anie.202204570","title":"Thionitrite (SNO <sup>−</sup> ) and Perthionitrite (SSNO <sup>−</sup> ) are Simple Synthons for Nitrosylated Iron Sulfur Clusters","abstract":"Abstract S/N crosstalk species derived from the interconnected reactivity of H 2 S and NO facilitate the transport of reactive sulfur and nitrogen species in signaling, transport, and regulatory processes. We report here that simple Fe 2+ ions, such as those that are bioavailable in the labile iron pool (LIP), react with thionitrite (SNO − ) and perthionitrite (SSNO − ) to yield the dinitrosyl iron complex [Fe(NO) 2 (S 5 )] − . In the reaction of FeCl 2 with SNO − we were able to isolate the unstable intermediate hydrosulfido mononitrosyl iron complex [FeCl 2 (NO)(SH)] − , which was characterized by X‐ray crystallography. We also show that [Fe(NO) 2 (S 5 )] − is a simple synthon for nitrosylated Fe−S clusters via its reduction with PPh 3 to yield Roussin's Red Salt ([Fe 2 S 2 (NO) 4 ] 2− ), which highlights the role of S/N crosstalk species in the assembly of fundamental Fe−S motifs.","journal":"Angewandte Chemie International Edition","year":2022,"id":257500,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":422030,"name":"Wen Fu","orcid":"0000-0003-0744-4707","position":1,"is_corresponding":false},{"id":334947,"name":"Lizhi Tao","orcid":"0000-0001-9921-2297","position":2,"is_corresponding":false},{"id":580381,"name":"Lev N. Zakharov","orcid":"0000-0002-8680-3474","position":3,"is_corresponding":false},{"id":334945,"name":"R. David Britt","orcid":"0000-0003-0889-8436","position":4,"is_corresponding":false},{"id":325445,"name":"Michael D. Pluth","orcid":"0000-0003-3604-653X","position":5,"is_corresponding":false},{"id":393451,"name":"Tobias J. Sherbow","orcid":"0000-0003-2205-1370","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T00:25:34.440699Z","pmid":"35580198","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}