{"doi":"10.1002/anie.202009092","title":"Total Synthesis of Malacidin A by β‐Hydroxyaspartic Acid Ligation‐Mediated Cyclization and Absolute Structure Establishment","abstract":"The development of novel antibiotics is critical to combating the growing emergence of drug-resistant pathogens. Malacidin A is a new member of the calcium-dependent antibiotic (CDAs) family with activity against antibiotic-resistant pathogens. Its mode of action is distinct from classical CDAs. However, the absolute structure of malacidin A has not been established. Herein, the total syntheses of malacidin A and its analogues are reported by a combination of Fmoc-based solid-phase peptide synthesis (SPPS) and β-hydroxyaspartic acid ligation-mediated peptide cyclization. The total synthesis enabled us to establish the absolute configuration of malacidin A, which is in agreement with those for natural malacidin A confirmed by advanced Marfey's analysis in our study.","journal":"Angewandte Chemie International Edition","year":2020,"id":96638,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":387658,"name":"Zhuo Shang","orcid":"0000-0002-5755-2629","position":1,"is_corresponding":false},{"id":480013,"name":"Nicholas Forelli","orcid":null,"position":2,"is_corresponding":false},{"id":480014,"name":"Kathy Hiu Laam Po","orcid":null,"position":3,"is_corresponding":false},{"id":478912,"name":"Sheng Chen","orcid":"0000-0003-3526-7808","position":4,"is_corresponding":false},{"id":406776,"name":"Sean F. Brady","orcid":"0000-0001-5967-8586","position":5,"is_corresponding":false},{"id":478913,"name":"Xuechen Li","orcid":"0000-0001-5465-7727","position":6,"is_corresponding":false},{"id":478911,"name":"Zhenquan Sun","orcid":"0000-0003-0877-9015","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-18T22:35:06.014648Z","pmid":"32725837","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}