{"doi":"10.1002/anie.202004464","title":"Concise Synthesis of (+)‐[<sup>13</sup>C<sub>4</sub>]‐Anatoxin‐a by Dynamic Kinetic Resolution of a Cyclic Iminium Ion","abstract":"Abstract An asymmetric total synthesis of [ 13 C 4 ]‐anatoxin‐a ([ 13 C 4 ]‐ 1 ) has been developed from commercially available ethyl [ 13 C 4 ]‐acetoacetate ([ 13 C 4 ]‐ 15 ). The unique requirements associated with isotope incorporation inspired a new, robust, and highly scalable route, providing access to 0.110 g of this internal standard for use in the detection and precise quantification of anatoxin‐a in freshwater. A highlight of the synthesis is a method that leverages a cyclic iminium ion racemization to achieve dynamic kinetic resolution in an enantioselective Morita–Baylis–Hillman (MBH) cyclization.","journal":"Angewandte Chemie International Edition","year":2020,"id":85382,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9471,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":437214,"name":"Artur K. Mailyan","orcid":null,"position":1,"is_corresponding":false},{"id":437215,"name":"Karen Y. Chen","orcid":null,"position":2,"is_corresponding":false},{"id":308842,"name":"Armen Zakarian","orcid":"0000-0002-9120-1232","position":3,"is_corresponding":false},{"id":437213,"name":"Jacob J. Lacharity","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T21:56:02.794896Z","pmid":"32304178","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}