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As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post‐PKS modifications.</jats:p>","journal":"Angewandte Chemie International Edition","year":2014,"id":652842,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1703203,"name":"Sei‐hyun Choi","orcid":null,"position":1,"is_corresponding":false},{"id":1703204,"name":"Byung‐sun Jeon","orcid":null,"position":2,"is_corresponding":false},{"id":1703205,"name":"Namho Kim","orcid":null,"position":3,"is_corresponding":false},{"id":1703206,"name":"Rongson Pongdee","orcid":null,"position":4,"is_corresponding":false},{"id":1703207,"name":"Qingquan Wu","orcid":null,"position":5,"is_corresponding":false},{"id":419939,"name":"Hung‐wen Liu","orcid":"0000-0001-8953-4794","position":6,"is_corresponding":false},{"id":722202,"name":"Hak Joong Kim","orcid":"0000-0002-3213-2230","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chemoenzymatic Synthesis of Spinosyn A","abstract":"<jats:title>Abstract</jats:title><jats:p>Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post‐PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post‐PKS modifications.</jats:p>","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25287333","pmcid":"PMC4266379","openalex_id":"https://openalex.org/W2147522606","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM035906","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM040541","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM035906","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM040541","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM035906","title":null}],"total_grants":5,"fwci":4.7569,"citation_percentile":0.94940494,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":4},{"year":2016,"count":6},{"year":2017,"count":6},{"year":2018,"count":7},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"green","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4266379","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc4266379?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4266379","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201407806","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201407806","host_type":"publisher"},{"url":"https://doi.org/10.1002/anie.201407806","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25287333","host_type":"repository"}],"fields_of_study":["Microbial Natural Products and Biosynthesis","Phytochemical compounds biological activities","Synthetic Organic Chemistry Methods","Chemistry","Medicine"],"mesh_terms":["Insecticides","Saccharopolyspora","Macrolides","Polyketide Synthases","Biosynthetic Pathways"],"keywords":["Polyketide","Biosynthesis","Chemistry","Stereochemistry","Polyketide synthase","Enzyme","Computational biology","Combinatorial chemistry","Biochemistry","Biology","Total synthesis","Spinosyns","Polyketide Macrolides","Post-polyketide Synthase Modifications"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:15:04.250383Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}