{"doi":"10.1002/ange.202419409","title":"Cationic Metal‐Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy","abstract":"Abstract Radiotherapy plays an important role in modern oncology, but its treatment efficacy is limited by the radioresistance of tumor cells. As a member of the inhibitor of apoptosis protein family, survivin plays a key role in developing radioresistance by mediating apoptosis evasion, promoting epithelial‐mesenchymal transition, and modulating cell cycle dynamics. Efficient downregulation of survivin expression presents a promising strategy to enhance the antitumor effects of radiotherapy. Herein, we report the design of a hafnium‐porphyrin‐based cationic metal‐organic layer (CMOL) with quaternary ammonium capping groups to deliver small interfering RNAs (siRNAs) for enhanced radiotherapy. The CMOL@siRNA nanoplatform not only increased energy deposition from X‐rays and reactive oxygen species generation via a unique radiotherapy‐radiodynamic therapy process, but also effectively delivered siRNAs to downregulate survivin expression and ameliorate radioresistance of cancer cells. Consequently, CMOL@siRNA in combination with low‐dose X‐ray irradiation demonstrated remarkable antitumor efficacy with 96.9 % and 91.4 % tumor growth inhibition in murine colorectal carcinoma and triple‐negative breast cancer models, respectively.","journal":"Angewandte Chemie","year":2024,"id":482209,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":662841,"name":"Xiaomin Jiang","orcid":"0000-0001-8304-4938","position":1,"is_corresponding":false},{"id":1237522,"name":"Zitong Wang","orcid":"0000-0003-2836-7720","position":2,"is_corresponding":false},{"id":1021272,"name":"Yingjie Fan","orcid":"0000-0003-1857-5788","position":3,"is_corresponding":false},{"id":1214470,"name":"Jinhong Li","orcid":"0000-0001-9242-4414","position":4,"is_corresponding":false},{"id":1237950,"name":"Cathleen Chow","orcid":null,"position":5,"is_corresponding":false},{"id":1237523,"name":"Chaoyu Wang","orcid":"0000-0001-9224-5061","position":6,"is_corresponding":false},{"id":1237524,"name":"Chenghua Deng","orcid":"0000-0003-0684-0812","position":7,"is_corresponding":false},{"id":230369,"name":"Wenbin Lin","orcid":"0000-0001-7035-7759","position":8,"is_corresponding":false},{"id":992792,"name":"Xin Ma","orcid":"0000-0001-6250-7737","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:07:14.349221Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}