{"doi":"10.1002/ange.202406779","title":"Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes","abstract":"Abstract Fluorinated cyclopropanes are highly desired pharmacophores in drug discovery owing to the rigid nature of the cyclopropane ring and the beneficial effects of C−F bonds on the pharmacokinetic properties, cell permeability, and metabolic stability of drug molecules. Herein a biocatalytic strategy for the stereoselective synthesis of mono‐fluorinated and gem‐difluoro cyclopropanes is reported though the use of engineered myoglobin‐based catalysts. In particular, this system allows for a broad range of gem‐difluoro alkenes to be cyclopropanated in the presence of diazoacetonitrile with excellent diastereo and enantiocontrol (up to 99 : 1 d.r. and 99 % e.e.), thereby enabling a transformation not currently accessible with chemocatalytic methods. The synthetic utility of the present approach is further exemplified through the gram‐scale synthesis of a key gem‐difluorinated cyclopropane intermediate useful for the preparation of fluorinated bioactive molecules.","journal":"Angewandte Chemie","year":2024,"id":459534,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9388,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":845669,"name":"Jadab Majhi","orcid":"0000-0001-8600-304X","position":1,"is_corresponding":false},{"id":1287078,"name":"Valentin Lehuédé","orcid":null,"position":2,"is_corresponding":false},{"id":1287079,"name":"Michelle Hendricks","orcid":null,"position":3,"is_corresponding":false},{"id":1286638,"name":"Katharina Neufeld","orcid":"0009-0002-0524-8438","position":4,"is_corresponding":false},{"id":1286639,"name":"Veronica Tona","orcid":"0000-0002-0736-6422","position":5,"is_corresponding":false},{"id":270966,"name":"Rudi Fasan","orcid":"0000-0003-4636-9578","position":6,"is_corresponding":false},{"id":1049958,"name":"Juan D. Villada","orcid":"0000-0002-9424-9194","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:03:59.428859Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}