{"doi":"10.1002/ange.202401003","title":"Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H<sub>2</sub>S Mediated Persulfidation","abstract":"Abstract The gasotransmitter hydrogen sulfide (H 2 S) is thought to be involved in the post‐translational modification of cysteine residues to produce reactive persulfides. A persulfide‐specific chemoselective proteomics approach with mammalian cells has identified a broad range of zinc finger (ZF) proteins as targets of persulfidation. Parallel studies with isolated ZFs show that persulfidation is mediated by Zn II , O 2 , and H 2 S, with intermediates involving oxygen‐ and sulfur‐based radicals detected by mass spectrometry and optical spectroscopies. A small molecule Zn II complex exhibits analogous reactivity with H 2 S and O 2 , giving a persulfidated product. These data show that Zn II is not just a biological structural element, but also plays a critical role in mediating H 2 S‐dependent persulfidation. ZF persulfidation appears to be a general post‐translational modification and a possible conduit for H 2 S signaling. This work has implications for our understanding of H 2 S‐mediated signaling and the regulation of ZFs in cellular physiology and development.","journal":"Angewandte Chemie","year":2024,"id":480270,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1222248,"name":"Jasper G. Ballot","orcid":null,"position":1,"is_corresponding":false},{"id":1221600,"name":"Thibaut Vignane","orcid":"0000-0002-3377-3187","position":2,"is_corresponding":false},{"id":1201014,"name":"Hongye Li","orcid":"0000-0001-7427-0706","position":3,"is_corresponding":false},{"id":1222249,"name":"Madison M. Worth","orcid":null,"position":4,"is_corresponding":false},{"id":379472,"name":"Ludovic Muller","orcid":"0000-0002-5987-6694","position":5,"is_corresponding":false},{"id":414296,"name":"Maxime A. Siegler","orcid":"0000-0003-4165-7810","position":6,"is_corresponding":false},{"id":242921,"name":"Maureen A. Kane","orcid":"0000-0002-5525-9170","position":7,"is_corresponding":false},{"id":676693,"name":"Miloš R. Filipović","orcid":"0000-0003-0060-0041","position":8,"is_corresponding":false},{"id":719341,"name":"David P. Goldberg","orcid":"0000-0003-4645-1045","position":9,"is_corresponding":false},{"id":323343,"name":"Sarah L. J. Michel","orcid":"0000-0002-6366-2453","position":10,"is_corresponding":false},{"id":1056581,"name":"Andrew T. Stoltzfus","orcid":null,"position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T02:06:58.305365Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}