{"doi":"10.1002/ange.202314531","title":"Side‐Chain Chemistry Governs Hierarchical Order of Charge‐Complementary β‐sheet Peptide Coassemblies","abstract":"Abstract Self‐assembly of proteinaceous biomolecules into functional materials with ordered structures that span length scales is common in nature yet remains a challenge with designer peptides under ambient conditions. This report demonstrates how charged side‐chain chemistry affects the hierarchical co‐assembly of a family of charge‐complementary β‐sheet‐forming peptide pairs known as CATCH(X+/Y−) at physiologic pH and ionic strength in water. In a concentration‐dependent manner, the CATCH(6K+) (Ac‐KQKFKFKFKQK‐Am) and CATCH(6D−) (Ac‐DQDFDFDFDQD‐Am) pair formed either β‐sheet‐rich microspheres or β‐sheet‐rich gels with a micron‐scale plate‐like morphology, which were not observed with other CATCH(X+/Y−) pairs. This hierarchical order was disrupted by replacing D with E, which increased fibril twisting. Replacing K with R, or mutating the N‐ and C‐terminal amino acids in CATCH(6K+) and CATCH(6D−) to Qs, increased observed co‐assembly kinetics, which also disrupted hierarchical order. Due to the ambient assembly conditions, active CATCH(6K+)‐green fluorescent protein fusions could be incorporated into the β‐sheet plates and microspheres formed by the CATCH(6K+/6D−) pair, demonstrating the potential to endow functionality.","journal":"Angewandte Chemie","year":2023,"id":369040,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1084705,"name":"Xin Dong","orcid":"0009-0002-7300-7660","position":1,"is_corresponding":false},{"id":1085239,"name":"Dillon T. Seroski","orcid":null,"position":2,"is_corresponding":false},{"id":1056855,"name":"Bethsymarie Soto Morales","orcid":null,"position":3,"is_corresponding":false},{"id":1084706,"name":"Kong M. Wong","orcid":"0000-0002-5298-3139","position":4,"is_corresponding":false},{"id":987526,"name":"Alicia S. Robang","orcid":"0000-0003-3857-9559","position":5,"is_corresponding":false},{"id":1085240,"name":"Lucas Melgar","orcid":null,"position":6,"is_corresponding":false},{"id":288665,"name":"Thomas E. Angelini","orcid":"0000-0002-0313-4341","position":7,"is_corresponding":false},{"id":580323,"name":"Anant K. Paravastu","orcid":"0000-0001-7183-1942","position":8,"is_corresponding":false},{"id":513452,"name":"Carol K. Hall","orcid":"0000-0002-7425-587X","position":9,"is_corresponding":false},{"id":418761,"name":"Gregory A. Hudalla","orcid":"0000-0003-2259-0809","position":10,"is_corresponding":false},{"id":418757,"name":"Renjie Liu","orcid":"0000-0002-3885-244X","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T01:15:28.704894Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}