{"doi":"10.1002/ange.202117233","title":"Palladium(II)‐Catalyzed Selective Arylation of Tertiary C−H Bonds of Cyclobutylmethyl Ketones Using Transient Directing Groups","abstract":"Abstract We report the first example of selective Pd II ‐catalyzed tertiary C−H activation of cyclobutylmethyl ketones using a transient directing group. An electron‐deficient 2‐pyridone ligand was identified as the optimal external ligand to enable tertiary C−H activation. A variety of cyclobutylmethyl ketones bearing quaternary carbon centers was readily accessed without preinstalling internal directing groups in up to 81 % yield and >95 : 5 regioisomeric ratios of tertiary C−H arylation to β‐methylene (β‐methyl) or γ‐C−H arylation.","journal":"Angewandte Chemie","year":2022,"id":291799,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9398,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":900604,"name":"Li‐Jun Xiao","orcid":"0000-0002-3998-3628","position":1,"is_corresponding":false},{"id":321498,"name":"Shaoqun Qian","orcid":"0000-0001-5991-1077","position":2,"is_corresponding":false},{"id":351360,"name":"Zhe Zhuang","orcid":"0000-0001-6679-0496","position":3,"is_corresponding":false},{"id":900605,"name":"An Liu","orcid":"0000-0003-3316-5496","position":4,"is_corresponding":false},{"id":321507,"name":"Jin‐Quan Yu","orcid":"0000-0003-3560-5774","position":5,"is_corresponding":false},{"id":886301,"name":"Jin‐Tang Cheng","orcid":null,"position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T00:30:38.420009Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}