{"doi":"10.1002/ange.202105559","title":"An Improved Turn Structure for Inducing β‐Hairpin Formation in Peptides","abstract":"Abstract Although β‐hairpins are widespread in proteins, there is no tool to coax any small peptide to adopt a β‐hairpin conformation, regardless of sequence. Here, we report that δ‐linked γ( R )‐methyl‐ornithine ( δ MeOrn) provides an improved β‐turn template for inducing a β‐hairpin conformation in peptides. We developed a synthesis of protected δ MeOrn as a building block suitable for use in Fmoc‐based solid‐phase peptide synthesis. The synthesis begins with l ‐leucine and affords gram quantities of the N α ‐Boc‐ N δ ‐Fmoc‐γ( R )‐methyl‐ornithine building block. X‐ray crystallography confirms that the δ MeOrn turn unit adopts a folded structure in a macrocyclic β‐hairpin peptide. CD and NMR spectroscopy allow comparison of the δ MeOrn turn template to the δ‐linked ornithine ( δ Orn) turn template that we previously introduced and to the popular d ‐Pro‐Gly turn template. These studies show that the folding of the δ MeOrn turn template is substantially better than that of δ Orn and is comparable to d ‐Pro‐Gly.","journal":"Angewandte Chemie","year":2021,"id":212501,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":735332,"name":"Andrew L. Sabol","orcid":"0000-0002-9932-312X","position":1,"is_corresponding":false},{"id":735333,"name":"Michał Wierzbicki","orcid":"0000-0002-9217-634X","position":2,"is_corresponding":false},{"id":735334,"name":"Patrick J. Salveson","orcid":"0000-0003-0962-6010","position":3,"is_corresponding":false},{"id":168285,"name":"James S. Nowick","orcid":"0000-0002-2273-1029","position":4,"is_corresponding":false},{"id":735331,"name":"Xingyue Li","orcid":"0000-0002-3032-4255","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T23:52:27.434608Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}