{"doi":"10.1002/ange.202002484","title":"Catalytic Behavior of Mono‐<i>N</i>‐Protected Amino‐Acid Ligands in Ligand‐Accelerated C−H Activation by Palladium(II)","abstract":"Abstract Mono‐N‐protected amino acids (MPAAs) are increasingly common ligands in Pd‐catalyzed C−H functionalization reactions. Previous studies have shown how these ligands accelerate catalytic turnover by facilitating the C−H activation step. Here, it is shown that MPAA ligands exhibit a second property commonly associated with ligand‐accelerated catalysis: the ability to support catalytic turnover at substoichiometric ligand‐to‐metal ratios. This catalytic role of the MPAA ligand is characterized in stoichiometric C−H activation and catalytic C−H functionalization reactions. Palladacycle formation with substrates bearing carboxylate and pyridine directing groups exhibit a 50–100‐fold increase in rate when only 0.05 equivalents of MPAA are present relative to Pd II . These and other mechanistic data indicate that facile exchange between MPAAs and anionic ligands coordinated to Pd II enables a single MPAA to support C−H activation at multiple Pd II centers.","journal":"Angewandte Chemie","year":2020,"id":107801,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9434,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471438,"name":"Joseph J. Gair","orcid":"0000-0002-2139-4702","position":1,"is_corresponding":false},{"id":305802,"name":"Kaylin N. Flesch","orcid":"0000-0002-8582-2614","position":2,"is_corresponding":false},{"id":251447,"name":"Ilia A. Guzei","orcid":"0000-0003-1976-7386","position":3,"is_corresponding":false},{"id":471439,"name":"Jared C. Lewis","orcid":"0000-0003-2800-8330","position":4,"is_corresponding":false},{"id":110277,"name":"Shannon S. Stahl","orcid":"0000-0002-9000-7665","position":5,"is_corresponding":false},{"id":305801,"name":"Chase A. Salazar","orcid":"0000-0002-2221-4865","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T23:12:39.385256Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}