{"doi":"10.1002/ange.201406192","title":"Kinetic Resolution of 1,1′‐Biaryl‐2,2′‐Diols and Amino Alcohols through NHC‐Catalyzed Atroposelective Acylation","abstract":"<jats:title>Abstract</jats:title><jats:p>We present here a highly efficient NHC‐catalyzed kinetic resolution of a wide range of 1,1′‐biaryl‐2,2′‐diols and amino alcohols to provide them in uniformly ≥99 % <jats:italic>ee</jats:italic>. This represents the first highly enantioselective catalytic acylation of axially chiral alcohols. The aldehyde backbone that is incorporated into the chiral acyl azolium intermediate was found to have a significant effect on the enantioselectivity of the process.</jats:p>","journal":"Angewandte Chemie","year":2014,"id":41176,"datarank":3.3339450119803873,"base_score":4.454347296253507,"endowment":4.454347296253507,"self_citation_contribution":0.6681520944380261,"citation_network_contribution":2.665792917542361,"self_endowment_contribution":0.6681520944380261,"citer_contribution":2.665792917542361,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":81,"citers_with_citation_signal":78,"citers_with_endowment":78,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":198741,"name":"Si Bei Poh","orcid":null,"position":1,"is_corresponding":false},{"id":73745,"name":"Yu Zhao","orcid":"0000-0003-4451-9907","position":2,"is_corresponding":false},{"id":198740,"name":"Shenci Lu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.454347296253507,"endowment":4.454347296253507,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18998881","pmcid":null,"openalex_id":"https://openalex.org/W4231889956","authors":[],"funders":[],"total_grants":0,"fwci":3.5781,"citation_percentile":0.92928552,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":9},{"year":2016,"count":5},{"year":2017,"count":6},{"year":2018,"count":9},{"year":2019,"count":12},{"year":2020,"count":13},{"year":2021,"count":9},{"year":2022,"count":12},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fange.201406192","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201406192","host_type":"publisher"},{"url":"https://doi.org/10.1002/ange.201406192","host_type":"journal"}],"fields_of_study":["Axial and Atropisomeric Chirality Synthesis","Asymmetric Synthesis and Catalysis","Molecular spectroscopy and chirality"],"mesh_terms":[],"keywords":["Kinetic resolution","Acylation","Enantioselective synthesis","Chemistry","Catalysis","Aldehyde","Organic chemistry","Combinatorial chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T21:56:24.288219Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}