{"doi":"10.1002/ana.410220503","title":"Abnormal glutamate metabolism in amyotrophic lateral sclerosis","abstract":"<jats:title>Abstract</jats:title><jats:p>Glutamate levels were determined in the fasting plasma of 22 patients with early‐stage primary amyotrophic lateral sclerosis (ALS) and compared to those of healthy and diseased controls. There was a significant increase (by approximately 100%, <jats:italic>p</jats:italic> &lt; 0.0005) in the plasma glutamate of the ALS patients as compared with the controls. Oral glutamate loading (60 mg of monosodium glutamate per kilogram of body weight, taken orally after overnight fasting) resulted in significantly greater elevations in the plasma glutamate and aspartate levels in the ALS patients than in the controls. Glutamate, a potentially neuroexcitotoxic compound, is thought to be the transmitter of the corticospinal tracts and certain spinal cord interneurons. A systemic defect in the metabolism of this amino acid may underlie primary ALS.</jats:p>","journal":"Annals of Neurology","year":1987,"id":678982,"datarank":0.8585377652928572,"base_score":5.723585101952381,"endowment":5.723585101952381,"self_citation_contribution":0.8585377652928572,"citation_network_contribution":0.0,"self_endowment_contribution":0.8585377652928572,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":305,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1774021,"name":"James T. Caroscio","orcid":null,"position":1,"is_corresponding":false},{"id":1774020,"name":"Andreas Plaitakis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Abnormal glutamate metabolism in amyotrophic lateral sclerosis","abstract":"<jats:title>Abstract</jats:title><jats:p>Glutamate levels were determined in the fasting plasma of 22 patients with early‐stage primary amyotrophic lateral sclerosis (ALS) and compared to those of healthy and diseased controls. There was a significant increase (by approximately 100%, <jats:italic>p</jats:italic> &lt; 0.0005) in the plasma glutamate of the ALS patients as compared with the controls. Oral glutamate loading (60 mg of monosodium glutamate per kilogram of body weight, taken orally after overnight fasting) resulted in significantly greater elevations in the plasma glutamate and aspartate levels in the ALS patients than in the controls. Glutamate, a potentially neuroexcitotoxic compound, is thought to be the transmitter of the corticospinal tracts and certain spinal cord interneurons. A systemic defect in the metabolism of this amino acid may underlie primary ALS.</jats:p>","is_dataset_classified":null,"base_score":5.723585101952381,"endowment":5.723585101952381,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2892463","pmcid":null,"openalex_id":"https://openalex.org/W2065845618","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS-16871","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS-11631","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR-71","title":null}],"total_grants":3,"fwci":10.4981,"citation_percentile":0.98784645,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":10},{"year":2014,"count":5},{"year":2015,"count":4},{"year":2016,"count":5},{"year":2017,"count":7},{"year":2018,"count":5},{"year":2019,"count":2},{"year":2020,"count":5},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fana.410220503","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.410220503","host_type":"publisher"},{"url":"https://doi.org/10.1002/ana.410220503","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2892463","host_type":"repository"}],"fields_of_study":["Amyotrophic Lateral Sclerosis Research","Ion channel regulation and function","Neuroscience and Neuropharmacology Research","Administration, Oral","Adult","Aged","Amino Acids","Amyotrophic Lateral Sclerosis","Glutamate Dehydrogenase","Glutamates","Glutamic Acid","Humans","Leukocytes","Middle Aged","Sodium Glutamate"],"mesh_terms":["Administration, Oral","Adult","Aged","Amino Acids","Amyotrophic Lateral Sclerosis","Glutamate Dehydrogenase","Glutamates","Humans","Leukocytes","Middle Aged","Sodium Glutamate","Glutamic Acid"],"keywords":["Amyotrophic lateral sclerosis","Glutamate receptor","Spinal cord","Internal medicine","Monosodium glutamate","Metabolism","Endocrinology","Medicine","Glutamic acid","Chemistry","Amino acid","Biochemistry","Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T11:57:29.816008Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}