{"doi":"10.1002/ana.27027","title":"Unexpected Low Rate of Amyloid‐β Pathology in Multiple Sclerosis Patients","abstract":"The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453-459.","journal":"Annals of Neurology","year":2024,"id":454696,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":310970,"name":"Suzanne E. Schindler","orcid":"0000-0002-1680-1465","position":1,"is_corresponding":false},{"id":273853,"name":"Amber Salter","orcid":"0000-0002-1088-110X","position":2,"is_corresponding":false},{"id":618696,"name":"Dana C. Perantie","orcid":"0000-0002-6380-8133","position":3,"is_corresponding":false},{"id":1278601,"name":"Nicole Shelley","orcid":null,"position":4,"is_corresponding":false},{"id":1259097,"name":"Bradley Judge","orcid":null,"position":5,"is_corresponding":false},{"id":320894,"name":"Sarah Keefe","orcid":"0000-0002-5943-0940","position":6,"is_corresponding":false},{"id":621188,"name":"Kristopher M. Kirmess","orcid":"0000-0002-0306-323X","position":7,"is_corresponding":false},{"id":621685,"name":"Philip B. Verghese","orcid":"0000-0003-4793-564X","position":8,"is_corresponding":false},{"id":621688,"name":"Kevin E. Yarasheski","orcid":"0000-0001-5436-2451","position":9,"is_corresponding":false},{"id":1094858,"name":"Venky Venkatesh","orcid":null,"position":10,"is_corresponding":false},{"id":67984,"name":"Cyrus A. Raji","orcid":"0000-0002-9086-0105","position":11,"is_corresponding":false},{"id":255192,"name":"Brian A. Gordon","orcid":"0000-0003-2109-2955","position":12,"is_corresponding":false},{"id":228359,"name":"Randall J. Bateman","orcid":"0000-0002-7729-1702","position":13,"is_corresponding":false},{"id":27593,"name":"John C. Morris","orcid":"0000-0001-9820-5618","position":14,"is_corresponding":false},{"id":320973,"name":"Robert T. Naismith","orcid":"0000-0003-0520-4283","position":15,"is_corresponding":false},{"id":27592,"name":"David M. Holtzman","orcid":"0000-0002-3400-0856","position":16,"is_corresponding":false},{"id":301875,"name":"Tammie L.S. Benzinger","orcid":"0000-0002-8114-0552","position":17,"is_corresponding":false},{"id":95053,"name":"Anne H. Cross","orcid":"0000-0003-0829-7569","position":18,"is_corresponding":false},{"id":437808,"name":"Matthew R. Brier","orcid":"0000-0001-5987-8705","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:03:12.720997Z","pmid":"38963256","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}