{"doi":"10.1002/ana.26812","title":"Improving Early Recognition of Treatment‐Responsive Causes of Rapidly Progressive Dementia: The <scp>STAM<sub>3</sub>P</scp> Score","abstract":"Objective To improve the timely recognition of patients with treatment‐responsive causes of rapidly progressive dementia (RPD). Methods A total of 226 adult patients with suspected RPD were enrolled in a prospective observational study and followed for up to 2 years. Diseases associated with RPD were characterized as potentially treatment‐responsive or non‐responsive, referencing clinical literature. Disease progression was measured using Clinical Dementia Rating® Sum‐of‐Box scores. Clinical and paraclinical features associated with treatment responsiveness were assessed using multivariable logistic regression. Findings informed the development of a clinical criterion optimized to recognize patients with potentially treatment‐responsive causes of RPD early in the diagnostic evaluation. Results A total of 155 patients met defined RPD criteria, of whom 86 patients (55.5%) had potentially treatment‐responsive causes. The median (range) age‐at‐symptom onset in patients with RPD was 68.9 years (range 22.0–90.7 years), with a similar number of men and women. Seizures, tumor (disease‐associated), magnetic resonance imaging suggestive of autoimmune encephalitis, mania, movement abnormalities, and pleocytosis (≥10 cells/mm 3 ) in cerebrospinal fluid at presentation were independently associated with treatment‐responsive causes of RPD after controlling for age and sex. Those features at presentation, as well as age‐at‐symptom onset &lt;50 years (ie, STAM 3 P), captured 82 of 86 (95.3%) cases of treatment‐responsive RPD. The presence of ≥3 STAM 3 P features had a positive predictive value of 100%. Interpretation Selected features at presentation reliably identified patients with potentially treatment‐responsive causes of RPD. Adaptation of the STAM 3 P screening score in clinical practice may minimize diagnostic delays and missed opportunities for treatment in patients with suspected RPD. ANN NEUROL 2024;95:237–248","journal":"Annals of Neurology","year":2023,"id":343354,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7626,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":444978,"name":"Philip W. Tipton","orcid":"0000-0003-4084-2248","position":1,"is_corresponding":false},{"id":230884,"name":"Yuka A. Martens","orcid":"0000-0002-5194-4269","position":2,"is_corresponding":false},{"id":1074796,"name":"Steven Dunham","orcid":"0000-0003-2840-3955","position":3,"is_corresponding":false},{"id":347892,"name":"Michael D. Geschwind","orcid":"0000-0003-2861-3776","position":4,"is_corresponding":false},{"id":27593,"name":"John C. Morris","orcid":"0000-0001-9820-5618","position":5,"is_corresponding":false},{"id":437808,"name":"Matthew R. Brier","orcid":"0000-0001-5987-8705","position":6,"is_corresponding":false},{"id":230889,"name":"Neill R. Graff‐Radford","orcid":"0000-0001-9847-9096","position":7,"is_corresponding":false},{"id":321439,"name":"Gregory S. Day","orcid":"0000-0001-5133-5538","position":8,"is_corresponding":false},{"id":762439,"name":"Nihal Satyadev","orcid":"0000-0001-7302-2348","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:11:21.758449Z","pmid":"37782554","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}