{"doi":"10.1002/ana.26610","title":"Decreased Cerebrospinal Fluid Amyloid β 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy","abstract":"OBJECTIVE: Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA. We studied the diagnostic potential of the peptides Aβ38, Aβ40, Aβ42, and Aβ43 in patients with sporadic CAA (sCAA), hereditary Dutch-type CAA (D-CAA), and Alzheimer disease (AD). METHODS: Aβ peptides were quantified by immunoassays in a discovery group (26 patients with sCAA and 40 controls), a validation group (40 patients with sCAA, 40 patients with AD, and 37 controls), and a group of 22 patients with D-CAA and 54 controls. To determine the diagnostic accuracy, the area under the curve (AUC) was calculated using a receiver operating characteristic curve with 95% confidence interval (CI). RESULTS: We found decreased levels of all Aβ peptides in sCAA patients and D-CAA patients compared to controls. The difference was most prominent for Aβ42 (AUC of sCAA vs controls for discovery: 0.90, 95% CI = 0.82-0.99; for validation: 0.94, 95% CI = 0.89-0.99) and Aβ43 (AUC of sCAA vs controls for discovery: 0.95, 95% CI = 0.88-1.00; for validation: 0.91, 95% CI = 0.83-1.0). All Aβ peptides except Aβ43 were also decreased in sCAA compared to AD (CSF Aβ38: AUC = 0.82, 95% CI = 0.71-0.93; CSF Aβ40: AUC = 0.88, 95% CI = 0.80-0.96; CSF Aβ42: AUC = 0.79, 95% CI = 0.66-0.92). INTERPRETATION: A combined biomarker panel of CSF Aβ38, Aβ40, Aβ42, and Aβ43 has potential to differentiate sCAA from AD and controls, and D-CAA from controls. 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Abdo","orcid":"0000-0002-5783-8643","position":9,"is_corresponding":false},{"id":962469,"name":"Ingeborg Rasing","orcid":"0000-0002-0953-7133","position":10,"is_corresponding":false},{"id":1029379,"name":"Sabine Voigt","orcid":"0000-0002-5182-6676","position":11,"is_corresponding":false},{"id":1029380,"name":"Emma A. Koemans","orcid":"0000-0003-0560-8077","position":12,"is_corresponding":false},{"id":1029381,"name":"Kanishk Kaushik","orcid":"0000-0003-1429-6853","position":13,"is_corresponding":false},{"id":256544,"name":"Andrew D. Warren","orcid":"0000-0002-5832-8178","position":14,"is_corresponding":false},{"id":251653,"name":"Steven M. Greenberg","orcid":"0000-0003-1792-8887","position":15,"is_corresponding":false},{"id":270064,"name":"Gunnar Brinkmalm","orcid":"0000-0001-6958-2393","position":16,"is_corresponding":false},{"id":277934,"name":"Gisela M. Terwindt","orcid":"0000-0003-3140-6882","position":17,"is_corresponding":false},{"id":85621,"name":"Marieke J.H. Wermer","orcid":"0000-0002-6838-9521","position":18,"is_corresponding":false},{"id":466030,"name":"Floris H.B.M. Schreuder","orcid":"0000-0002-7815-0207","position":19,"is_corresponding":false},{"id":249221,"name":"Catharina J.M. Klijn","orcid":"0000-0002-8495-4578","position":20,"is_corresponding":false},{"id":466031,"name":"Marcel M. 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