{"doi":"10.1002/ana.26429","title":"Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy","abstract":"Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358-363.","journal":"Annals of Neurology","year":2022,"id":255400,"datarank":0.9213442336541209,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.4646658679956074,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.4646658679956074,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":9,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9652,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":638860,"name":"Wai‐Ying Wendy Yau","orcid":"0000-0002-7597-7647","position":1,"is_corresponding":false},{"id":255193,"name":"Stephanie A. Schultz","orcid":"0000-0001-8460-4415","position":2,"is_corresponding":false},{"id":263295,"name":"Aaron P. Schultz","orcid":"0000-0002-0418-0999","position":3,"is_corresponding":false},{"id":263293,"name":"Matthew R. Scott","orcid":"0000-0003-1404-4437","position":4,"is_corresponding":false},{"id":362489,"name":"Maged Goubran","orcid":"0000-0001-5880-0818","position":5,"is_corresponding":false},{"id":903614,"name":"Parisa Mojiri‐Forooshani","orcid":null,"position":6,"is_corresponding":false},{"id":320898,"name":"Nelly Joseph‐Mathurin","orcid":"0000-0002-9735-5152","position":7,"is_corresponding":false},{"id":108589,"name":"Kejal Kantarci","orcid":"0000-0002-8001-2081","position":8,"is_corresponding":false},{"id":903615,"name":"Greg M. Preboske","orcid":null,"position":9,"is_corresponding":false},{"id":85621,"name":"Marieke J.H. Wermer","orcid":"0000-0002-6838-9521","position":10,"is_corresponding":false},{"id":49956,"name":"Clifford R. Jack","orcid":"0000-0001-7916-622X","position":11,"is_corresponding":false},{"id":301875,"name":"Tammie L.S. Benzinger","orcid":"0000-0002-8114-0552","position":12,"is_corresponding":false},{"id":236157,"name":"Kevin Taddei","orcid":"0000-0002-8106-7957","position":13,"is_corresponding":false},{"id":236176,"name":"Hamid R. Sohrabi","orcid":"0000-0001-8017-8682","position":14,"is_corresponding":false},{"id":55000,"name":"Reisa A. Sperling","orcid":"0000-0003-1535-6133","position":15,"is_corresponding":false},{"id":232961,"name":"Keith A. Johnson","orcid":"0000-0002-5916-6043","position":16,"is_corresponding":false},{"id":228359,"name":"Randall J. Bateman","orcid":"0000-0002-7729-1702","position":17,"is_corresponding":false},{"id":226618,"name":"Ralph N. Martins","orcid":"0000-0002-4828-9363","position":18,"is_corresponding":false},{"id":251653,"name":"Steven M. Greenberg","orcid":"0000-0003-1792-8887","position":19,"is_corresponding":false},{"id":301880,"name":"Jasmeer P. Chhatwal","orcid":"0000-0002-7792-1698","position":20,"is_corresponding":false},{"id":903616,"name":"DIAN Investigators","orcid":null,"position":21,"is_corresponding":false},{"id":467490,"name":"Zahra Shirzadi","orcid":"0000-0001-6854-9356","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:12.987829Z","pmid":"35670654","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}