{"doi":"10.1002/ana.26250","title":"Genetically Determined Low‐Density Lipoprotein Cholesterol and Risk of Subarachnoid Hemorrhage","abstract":"We evaluated whether genetically elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with lower risk of intracranial aneurysms and subarachnoid hemorrhage (IA/SAH). We conducted a 2-sample Mendelian randomization (MR) study. Our primary analysis used the inverse-variance weighted method. In secondary analyses, we implemented the MR-PRESSO method, restricted our analysis to LDL-C-specific instruments, and performed multivariate MR. A 1-mmol/l increase in genetically instrumented LDL-C levels was associated with a 17% lower risk of IA/SAH (odds ratio = 0.83, 95% confidence interval = 0.73-0.94, p = 0.004). Results remained consistent in secondary and multivariate analyses (all p < 0.05). Our results provide evidence for an inverse causal relationship between LDL-C levels and risk of IA/SAH. ANN NEUROL 2022;91:145-149.","journal":"Annals of Neurology","year":2021,"id":195833,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.964,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":700463,"name":"Cameron Both","orcid":"0000-0001-8907-9533","position":1,"is_corresponding":false},{"id":383752,"name":"Natalia Szejko","orcid":"0000-0001-6160-9221","position":2,"is_corresponding":false},{"id":623205,"name":"Audrey C. Leasure","orcid":"0000-0002-9462-5022","position":3,"is_corresponding":false},{"id":701276,"name":"Safa Abdelhakim","orcid":null,"position":4,"is_corresponding":false},{"id":701275,"name":"Victor Torres‐Lopez","orcid":null,"position":5,"is_corresponding":false},{"id":645704,"name":"Stacy Brown","orcid":null,"position":6,"is_corresponding":false},{"id":434039,"name":"Charles Matouk","orcid":"0000-0003-3234-9541","position":7,"is_corresponding":false},{"id":36522,"name":"Murat Günel","orcid":"0000-0002-2290-7055","position":8,"is_corresponding":false},{"id":256547,"name":"Kevin N. Sheth","orcid":"0000-0003-2003-5473","position":9,"is_corresponding":false},{"id":256546,"name":"Guido J. Falcone","orcid":"0000-0002-6407-0302","position":10,"is_corresponding":false},{"id":64751,"name":"Julián Acosta","orcid":"0000-0001-6497-5454","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T23:50:11.609550Z","pmid":"34709661","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}