{"doi":"10.1002/ana.22619","title":"Optic radiation tractography and vision in anterior temporal lobe resection","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective:</jats:title><jats:p>Anterior temporal lobe resection (ATLR) is an effective treatment for refractory temporal lobe epilepsy but may result in a contralateral superior visual field deficit (VFD) that precludes driving in the seizure‐free patient. Diffusion tensor imaging (DTI) tractography can delineate the optic radiation preoperatively and stratify risk. It would be advantageous to incorporate display of tracts into interventional magnetic resonance imaging (MRI) to guide surgery.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>We studied 20 patients undergoing ATLR. Structural MRI scans, DTI, and visual fields were acquired before and 3 to 12 months following surgery. Tractography of the optic radiation was performed on preoperative images and propagated onto postoperative images. The anteroposterior extent of the damage to Meyer's loop was determined, and visual loss was quantified using Goldmann perimetry.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Twelve patients (60%) suffered a VFD (10–92% of upper quadrant; median, 39%). Image registration took &lt;3 minutes and predicted that Meyer's loop was 4.4 to 18.7mm anterior to the resection margin in these patients, but 0.0 to 17.6mm behind the resection margin in the 8 patients without VFD. The extent of damage to Meyer's loop significantly correlated with the degree of VFD and explained 65% of the variance in this measure.</jats:p></jats:sec><jats:sec><jats:title>Interpretation:</jats:title><jats:p>The optic radiation can be accurately delineated by tractography and propagated onto postoperative images. The technique is fast enough to propagate accurate preoperative tractography onto intraoperative scans acquired during neurosurgery, with the potential to reduce the risk of VFD. ANN NEUROL 2012;</jats:p></jats:sec>","journal":"Annals of Neurology","year":2012,"id":643229,"datarank":0.6846522287201755,"base_score":4.564348191467836,"endowment":4.564348191467836,"self_citation_contribution":0.6846522287201755,"citation_network_contribution":0.0,"self_endowment_contribution":0.6846522287201755,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":95,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":628909,"name":"Pankaj Daga","orcid":"0000-0002-2508-0903","position":1,"is_corresponding":false},{"id":1673499,"name":"Jason Stretton","orcid":null,"position":2,"is_corresponding":false},{"id":534810,"name":"Marc Modat","orcid":"0000-0002-5277-8530","position":3,"is_corresponding":false},{"id":1673500,"name":"Mark R. Symms","orcid":null,"position":4,"is_corresponding":false},{"id":1076638,"name":"Andrew W. McEvoy","orcid":"0000-0002-1078-3761","position":5,"is_corresponding":false},{"id":840470,"name":"Sebastien Ourselin","orcid":null,"position":6,"is_corresponding":false},{"id":52293,"name":"John S. Duncan","orcid":"0000-0002-1373-0681","position":7,"is_corresponding":false},{"id":52294,"name":"Gavin P. Winston","orcid":"0000-0001-9395-1478","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Optic radiation tractography and vision in anterior temporal lobe resection","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective:</jats:title><jats:p>Anterior temporal lobe resection (ATLR) is an effective treatment for refractory temporal lobe epilepsy but may result in a contralateral superior visual field deficit (VFD) that precludes driving in the seizure‐free patient. Diffusion tensor imaging (DTI) tractography can delineate the optic radiation preoperatively and stratify risk. It would be advantageous to incorporate display of tracts into interventional magnetic resonance imaging (MRI) to guide surgery.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>We studied 20 patients undergoing ATLR. Structural MRI scans, DTI, and visual fields were acquired before and 3 to 12 months following surgery. Tractography of the optic radiation was performed on preoperative images and propagated onto postoperative images. The anteroposterior extent of the damage to Meyer's loop was determined, and visual loss was quantified using Goldmann perimetry.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Twelve patients (60%) suffered a VFD (10–92% of upper quadrant; median, 39%). Image registration took &lt;3 minutes and predicted that Meyer's loop was 4.4 to 18.7mm anterior to the resection margin in these patients, but 0.0 to 17.6mm behind the resection margin in the 8 patients without VFD. The extent of damage to Meyer's loop significantly correlated with the degree of VFD and explained 65% of the variance in this measure.</jats:p></jats:sec><jats:sec><jats:title>Interpretation:</jats:title><jats:p>The optic radiation can be accurately delineated by tractography and propagated onto postoperative images. The technique is fast enough to propagate accurate preoperative tractography onto intraoperative scans acquired during neurosurgery, with the potential to reduce the risk of VFD. ANN NEUROL 2012;</jats:p></jats:sec>","is_dataset_classified":null,"base_score":4.564348191467836,"endowment":4.564348191467836,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22451201","pmcid":"PMC3698700","openalex_id":"https://openalex.org/W2002815055","authors":[],"funders":[{"funder_name":"Cancer Research UK","grant_id":"C1519/A10331","title":null},{"funder_name":"Medical Research Council","grant_id":"G0802012","title":"Translation of novel imaging techniques into clinical use for patients with epilepsy"},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"NF-SI-0509-10161","title":null},{"funder_name":"Wellcome Trust","grant_id":"083148","title":"The consequences of temporal lobe epilepsy surgery ."},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"}],"total_grants":5,"fwci":6.8774,"citation_percentile":0.97188094,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":7},{"year":2014,"count":19},{"year":2015,"count":12},{"year":2016,"count":6},{"year":2017,"count":9},{"year":2018,"count":9},{"year":2019,"count":6},{"year":2020,"count":3},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.22619","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.22619","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fana.22619","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.22619","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ana.22619","host_type":"publisher"},{"url":"https://doi.org/10.1002/ana.22619","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22451201","host_type":"repository"},{"url":"https://discovery.ucl.ac.uk/id/eprint/1331004/","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3698700","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3698700","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3698700","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3698700?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1002/ana.22619","host_type":""},{"url":"https://dx.doi.org/10.1002/ana.22619","host_type":""},{"url":"https://discovery-pp.ucl.ac.uk/id/eprint/1331004/","host_type":""}],"fields_of_study":["Advanced Neuroimaging Techniques and Applications","Epilepsy research and treatment","Glioma Diagnosis and Treatment","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adolescent","Adult","Epilepsy, Temporal Lobe","Female","Humans","Male","Middle Aged","Postoperative Complications","Preoperative Care","Temporal Lobe","Vision, Ocular","Vision Disorders","Visual Fields","Visual Pathways","Young Adult","Diffusion Tensor Imaging"],"keywords":["Optic radiation","Tractography","Magnetic resonance imaging","Temporal lobe","Diffusion MRI","Medicine","Visual field","Radiology","Epilepsy surgery","Lobe","Neurosurgery","Epilepsy","Ophthalmology","Anatomy","Adult","Male","Adolescent","Vision","Vision Disorders","Original Articles","Middle Aged","Young Adult","Diffusion Tensor Imaging","Postoperative Complications","Epilepsy, Temporal Lobe","Ocular","Preoperative Care","Humans","Female","Visual Pathways","Visual Fields","Vision, Ocular"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T14:16:48.509754Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}