{"doi":"10.1002/ana.22333","title":"Amyloid‐β associated cortical thinning in clinically normal elderly","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective:</jats:title><jats:p>Both amyloid‐β (Aβ) deposition and brain atrophy are associated with Alzheimer's disease (AD) and the disease process likely begins many years before symptoms appear. We sought to determine whether clinically normal (CN) older individuals with Aβ deposition revealed by positron emission tomography (PET) imaging using Pittsburgh Compound B (PiB) also have evidence of both cortical thickness and hippocampal volume reductions in a pattern similar to that seen in AD.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>A total of 119 older individuals (87 CN subjects and 32 patients with mild AD) underwent PiB PET and high‐resolution structural magnetic resonance imaging (MRI). Regression models were used to relate PiB retention to cortical thickness and hippocampal volume.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>We found that PiB retention in CN subjects was (1) age‐related and (2) associated with cortical thickness reductions, particularly in parietal and posterior cingulate regions extending into the precuneus, in a pattern similar to that observed in mild AD. Hippocampal volume reduction was variably related to Aβ deposition.</jats:p></jats:sec><jats:sec><jats:title>Interpretation:</jats:title><jats:p>We conclude that Aβ deposition is associated with a pattern of cortical thickness reduction consistent with AD prior to the development of cognitive impairment. ANN NEUROL 2010;</jats:p></jats:sec>","journal":"Annals of Neurology","year":2011,"id":610897,"datarank":0.8778303719661713,"base_score":5.8522024797744745,"endowment":5.8522024797744745,"self_citation_contribution":0.8778303719661713,"citation_network_contribution":0.0,"self_endowment_contribution":0.8778303719661713,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":347,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":67969,"name":"Trey Hedden","orcid":null,"position":1,"is_corresponding":false},{"id":450263,"name":"Jeremy Carmasin","orcid":null,"position":2,"is_corresponding":false},{"id":1570833,"name":"Jacqueline Maye","orcid":null,"position":3,"is_corresponding":false},{"id":68026,"name":"Dorene M. Rentz","orcid":null,"position":4,"is_corresponding":false},{"id":499145,"name":"Deepti Putcha","orcid":"0000-0001-5575-5572","position":5,"is_corresponding":false},{"id":19604,"name":"Bruce Fischl","orcid":"0000-0002-2413-1115","position":6,"is_corresponding":false},{"id":342687,"name":"Douglas N. Greve","orcid":"0000-0002-0610-0155","position":7,"is_corresponding":false},{"id":313455,"name":"Gad A. Marshall","orcid":"0000-0002-9096-2355","position":8,"is_corresponding":false},{"id":301881,"name":"Stephen Salloway","orcid":"0000-0002-2631-0942","position":9,"is_corresponding":false},{"id":1570834,"name":"Donald Marks","orcid":null,"position":10,"is_corresponding":false},{"id":16290,"name":"Randy L. Buckner","orcid":"0000-0001-6422-8037","position":11,"is_corresponding":false},{"id":55000,"name":"Reisa A. Sperling","orcid":"0000-0003-1535-6133","position":12,"is_corresponding":false},{"id":232961,"name":"Keith A. Johnson","orcid":"0000-0002-5916-6043","position":13,"is_corresponding":false},{"id":621353,"name":"J. Alex Becker","orcid":"0000-0001-7435-1338","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Amyloid‐β associated cortical thinning in clinically normal elderly","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective:</jats:title><jats:p>Both amyloid‐β (Aβ) deposition and brain atrophy are associated with Alzheimer's disease (AD) and the disease process likely begins many years before symptoms appear. We sought to determine whether clinically normal (CN) older individuals with Aβ deposition revealed by positron emission tomography (PET) imaging using Pittsburgh Compound B (PiB) also have evidence of both cortical thickness and hippocampal volume reductions in a pattern similar to that seen in AD.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>A total of 119 older individuals (87 CN subjects and 32 patients with mild AD) underwent PiB PET and high‐resolution structural magnetic resonance imaging (MRI). Regression models were used to relate PiB retention to cortical thickness and hippocampal volume.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>We found that PiB retention in CN subjects was (1) age‐related and (2) associated with cortical thickness reductions, particularly in parietal and posterior cingulate regions extending into the precuneus, in a pattern similar to that observed in mild AD. Hippocampal volume reduction was variably related to Aβ deposition.</jats:p></jats:sec><jats:sec><jats:title>Interpretation:</jats:title><jats:p>We conclude that Aβ deposition is associated with a pattern of cortical thickness reduction consistent with AD prior to the development of cognitive impairment. ANN NEUROL 2010;</jats:p></jats:sec>","is_dataset_classified":null,"base_score":5.8522024797744745,"endowment":5.8522024797744745,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21437929","pmcid":"PMC3117980","openalex_id":"https://openalex.org/W2098580427","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"1K23AG033634","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P01-AG036694","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P50-AG00513421","title":null},{"funder_name":"NIA NIH HHS","grant_id":"K24 AG035007","title":null},{"funder_name":"NIA NIH HHS","grant_id":"K23 AG033634","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG021910","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG037497","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01-AG021910","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG034556","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01-AG027435-S1","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P01 AG036694","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG027435","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01AG021910-05","title":"Functional-anatomic exploration of cognitive control"},{"funder_name":"National Institutes of Health","grant_id":"5K23AG033634-04","title":"PIB binding, hypometabolism, apathy and executive dysfunction in MCI and AD"},{"funder_name":"National Institutes of Health","grant_id":"1U01AG032438-01","title":"Biomarker"},{"funder_name":"National Institutes of Health","grant_id":"3P01AG036694-09S2","title":"Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG027435-05","title":"Evolution of memory-related fMRI activation over the course of MCI and AD"},{"funder_name":"National Institutes of Health","grant_id":"5R03AG023916-02","title":"Aging Brain: DTI, Subcortical Ischemia and Behavioral"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":20,"fwci":14.35,"citation_percentile":0.9951278,"influential_citations":0,"citation_trend":[{"year":2012,"count":31},{"year":2013,"count":35},{"year":2014,"count":38},{"year":2015,"count":27},{"year":2016,"count":18},{"year":2017,"count":23},{"year":2018,"count":24},{"year":2019,"count":22},{"year":2020,"count":32},{"year":2021,"count":18},{"year":2022,"count":13},{"year":2023,"count":14},{"year":2024,"count":13},{"year":2025,"count":12},{"year":2026,"count":7}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.22333","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.22333","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fana.22333","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.22333","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ana.22333","host_type":"publisher"},{"url":"https://doi.org/10.1002/ana.22333","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21437929","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117980","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3117980","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3117980?pdf=render","host_type":"Europe_PMC"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117980","host_type":""},{"url":"http://dx.doi.org/10.1002/ana.22333","host_type":""},{"url":"https://dx.doi.org/10.1002/ana.22333","host_type":""}],"fields_of_study":["Dementia and Cognitive Impairment Research","Alzheimer's disease research and treatments","Cerebrospinal fluid and hydrocephalus","03 medical and health sciences","0302 clinical medicine","Age Factors","Aged","Aged, 80 and over","Aging","Alzheimer Disease","Amyloid beta-Peptides","Analysis of Variance","Aniline Compounds","Brain Mapping","Cerebral Cortex","Female","Hippocampus","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Positron-Emission Tomography","Statistics as Topic","Thiazoles"],"mesh_terms":["Age Factors","Aged","Aged, 80 and over","Aging","Alzheimer Disease","Analysis of Variance","Aniline Compounds","Brain Mapping","Cerebral Cortex","Female","Hippocampus","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Statistics as Topic","Thiazoles","Amyloid beta-Peptides","Positron-Emission Tomography"],"keywords":["Precuneus","Pittsburgh compound B","Posterior cingulate","Magnetic resonance imaging","Atrophy","Hippocampal formation","Alzheimer's disease","Neuroimaging","Pathology","Medicine","Hippocampus","Psychology","Neuroscience","Cardiology","Cortex (anatomy)","Internal medicine","Disease","Radiology","Cognition","Aged, 80 and over","Cerebral Cortex","Male","Aging","Analysis of Variance","Brain Mapping","Amyloid beta-Peptides","Aniline Compounds","Statistics as Topic","Age Factors","Original Articles","Middle Aged","Thiazoles","Alzheimer Disease","Positron-Emission Tomography","Humans","Female","Aged"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T12:36:37.653652Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}