{"doi":"10.1002/ana.22099","title":"Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy","abstract":"<jats:title>Abstract</jats:title><jats:p>Advanced cerebrovascular β‐amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*‐weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (<jats:italic>p</jats:italic> = 0.002) and declined with increasing distance from the microbleed (<jats:italic>p</jats:italic> &lt; 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. Ann Neurol 2010</jats:p>","journal":"Annals of Neurology","year":2010,"id":605880,"datarank":0.7909499337845621,"base_score":5.272999558563747,"endowment":5.272999558563747,"self_citation_contribution":0.7909499337845621,"citation_network_contribution":0.0,"self_endowment_contribution":0.7909499337845621,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":194,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547584,"name":"Maureen E. Skehan","orcid":null,"position":1,"is_corresponding":false},{"id":1555137,"name":"Muhammad A. 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We used T2*‐weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (<jats:italic>p</jats:italic> = 0.002) and declined with increasing distance from the microbleed (<jats:italic>p</jats:italic> &lt; 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. 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