{"doi":"10.1002/alz.71120","title":"Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION</jats:title>\n                    <jats:p>Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS</jats:title>\n                    <jats:p>We analyzed 2,722 participants from the National Alzheimer's Coordinating Center, including 886 AD patients and 1,836 cognitively normal controls. Neuroimaging assessed brain volumes, while depressive symptoms were measured using the Geriatric Depression Scale. Multiple linear regression and mediation analyses evaluated associations between brain structure, cognitive function, and depression.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS</jats:title>\n                    <jats:p>\n                      AD patients had significantly higher rates of depressive symptoms (35.3% vs. 14.7%;\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.001) and cognitive impairments (mean Mini‐Mental State Examination [MMSE]: 23.1 vs. 28.9;\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.001). Hippocampal atrophy mediated the relationship between depression and AD (indirect effect = −0.107;\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.001).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION</jats:title>\n                    <jats:p>Hippocampal atrophy significantly mediates the relationship between depression and AD, suggesting targeted interventions may enhance patient outcomes.</jats:p>\n                  </jats:sec>","journal":"Alzheimer's &amp; Dementia","year":2026,"id":639419,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1379734,"name":"Jiaxin Yang","orcid":"0000-0001-9286-0558","position":1,"is_corresponding":false},{"id":1412971,"name":"Xiaoyang Lei","orcid":null,"position":2,"is_corresponding":false},{"id":1407053,"name":"Ming Zhang","orcid":"0009-0003-0087-3493","position":3,"is_corresponding":false},{"id":258849,"name":"Yi Chen","orcid":"0000-0001-5329-4987","position":4,"is_corresponding":false},{"id":1661271,"name":"Xiaoxue Peng","orcid":null,"position":5,"is_corresponding":false},{"id":703297,"name":"Dian He","orcid":"0000-0003-0550-6249","position":6,"is_corresponding":false},{"id":71248,"name":"Chao Tang","orcid":"0000-0003-1474-3705","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION</jats:title>\n                    <jats:p>Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS</jats:title>\n                    <jats:p>We analyzed 2,722 participants from the National Alzheimer's Coordinating Center, including 886 AD patients and 1,836 cognitively normal controls. Neuroimaging assessed brain volumes, while depressive symptoms were measured using the Geriatric Depression Scale. Multiple linear regression and mediation analyses evaluated associations between brain structure, cognitive function, and depression.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS</jats:title>\n                    <jats:p>\n                      AD patients had significantly higher rates of depressive symptoms (35.3% vs. 14.7%;\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.001) and cognitive impairments (mean Mini‐Mental State Examination [MMSE]: 23.1 vs. 28.9;\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.001). Hippocampal atrophy mediated the relationship between depression and AD (indirect effect = −0.107;\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.001).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION</jats:title>\n                    <jats:p>Hippocampal atrophy significantly mediates the relationship between depression and AD, suggesting targeted interventions may enhance patient outcomes.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41611638","pmcid":"PMC12854940","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institute on Aging","grant_id":"P30AG062429","title":null},{"funder_name":"National Institute on 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Institute on Aging","grant_id":"P30AG072976","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG072975","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG072978","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG072977","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG066519","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG062677","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG079280","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG062422","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG066511","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG072946","title":null},{"funder_name":"National Institute on Aging","grant_id":"P30AG062715","title":null},{"funder_name":"National Institute on 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Institute on Aging","grant_id":"P30AG072959","title":null},{"funder_name":"Boston University","grant_id":"P30AG013846","title":null},{"funder_name":"Indiana University","grant_id":"R01AG19771","title":null},{"funder_name":"Indiana University","grant_id":"P30AG10133","title":null},{"funder_name":"Indiana University","grant_id":"R01AG061788","title":null},{"funder_name":"Indiana University","grant_id":"R01AG053993","title":null},{"funder_name":"Indiana University","grant_id":"U01AG057195","title":null},{"funder_name":"Indiana University","grant_id":"U19AG063911","title":null},{"funder_name":"Mayo Clinic","grant_id":"P50AG016574","title":null},{"funder_name":"New York University","grant_id":"P30AG066512‐01S2","title":null},{"funder_name":"New York University","grant_id":"R01AG056031","title":null},{"funder_name":"New York University","grant_id":"R01AG056531","title":null},{"funder_name":"Oregon Health and Science University","grant_id":"P30AG008017","title":null},{"funder_name":"Oregon Health and Science University","grant_id":"R56AG074321","title":null},{"funder_name":"Rush University","grant_id":"P30AG010161","title":null},{"funder_name":"University of California, Davis","grant_id":"P30AG10129","title":null},{"funder_name":"University of California, Irvine","grant_id":"P50AG016573","title":null},{"funder_name":"University of Kansas","grant_id":"P30AG035982","title":null},{"funder_name":"University of Kentucky","grant_id":"P30AG028283‐15S1","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"200775","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"U19NS120384","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"R01AG068338","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"S10OD026738‐01","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"R01AG058724","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"R35AG072262","title":null},{"funder_name":"Cure Alzheimer's 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University","grant_id":"R01AG077444","title":null},{"funder_name":"North western University","grant_id":"U19AG073153","title":null},{"funder_name":"Washington University, St.Louis","grant_id":"R01AG021910","title":null},{"funder_name":"Washington University, St.Louis","grant_id":"R01AG043434","title":null},{"funder_name":"North western University","grant_id":"R01DC008552","title":null},{"funder_name":"North western University","grant_id":"R01NS075075","title":null},{"funder_name":"University of Pennsylvania-State of PA project","grant_id":"2019NF4100087335","title":null},{"funder_name":"North western University","grant_id":"P30AG013854","title":null},{"funder_name":"Clevel and ADRC","grant_id":"P30AG062428","title":null},{"funder_name":"Cure Alzheimer's Fund","grant_id":"S10OD026738-01","title":null},{"funder_name":"University of Michigan ADRC","grant_id":"P30AG053760","title":null},{"funder_name":"New York University","grant_id":"P30AG066512-01S2","title":null},{"funder_name":"Avid 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