{"doi":"10.1002/alz.70927","title":"Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study","abstract":"INTRODUCTION: Apolipoprotein E allele 4 (APOE ε4) is the main genetic risk factor for late-onset Alzheimer's disease (AD), but most evidence comes from White populations in high-income countries. We investigated APOE and AD pathology in an ethnically diverse Brazilian autopsy cohort. METHODS: This cross-sectional study used Biobank for Aging Studies (BAS) data. AD pathology was evaluated with Braak, Consortium to Establish a Registry for Alzheimer's Disease, and Thal criteria. APOE genotypes were obtained from blood or brain tissue. Regression models were adjusted for age, sex, race, and education; interaction with race was tested. RESULTS: Among 1391 participants (mean age 75.1 ± 12.4 years, 50% women, 64% White), APOE ε4showed a dose response with greater AD pathological burden and higher odds of AD diagnosis, while APOE ε2/X was protective. APOE ε4/ε4 did not show full penetrance across age groups. Associations were similar in White and Black individuals. DISCUSSION: APOE ε4was strongly associated with AD pathology, with consistent associations across racial groups. HIGHLIGHTS: APOE ε4 increased AD neuropathological burden in Brazilians. APOE ε2/εX was protective against AD pathology. APOE ε4/ε4did not show full penetrance across age groups. Associations between APOE and AD pathology were similar by race. Large multiethnic autopsy study expands evidence beyond high-income country studies.","journal":"Alzheimer s & Dementia","year":2025,"id":548891,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":22.178386323199504,"corpus_rank":9377,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5128,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1442571,"name":"Regina Silva Paradela","orcid":"0000-0003-3155-4682","position":1,"is_corresponding":false},{"id":413863,"name":"Renata Elaine Paraízo Leite","orcid":"0000-0002-5878-398X","position":2,"is_corresponding":false},{"id":1235067,"name":"Vítor Ribeiro Paes","orcid":"0000-0001-8752-5624","position":3,"is_corresponding":false},{"id":413866,"name":"Carlos Augusto Pasqualucci","orcid":"0000-0001-6608-2473","position":4,"is_corresponding":false},{"id":1036751,"name":"Eduardo Ferriolli","orcid":"0000-0002-5028-2451","position":5,"is_corresponding":false},{"id":349388,"name":"Mayana Zatz","orcid":null,"position":6,"is_corresponding":false},{"id":1442572,"name":"Gabriela Cicalise de Souza Santos","orcid":"0000-0003-3433-5207","position":7,"is_corresponding":false},{"id":1443059,"name":"Marvin Afonso Longo Salvador de Alexandria","orcid":null,"position":8,"is_corresponding":false},{"id":291558,"name":"Ana C. Pereira","orcid":"0000-0003-2524-7969","position":9,"is_corresponding":false},{"id":232591,"name":"Juan Fortea","orcid":"0000-0002-1340-638X","position":10,"is_corresponding":false},{"id":661660,"name":"Michel Satya Naslavsky","orcid":"0000-0002-9068-1713","position":11,"is_corresponding":false},{"id":109118,"name":"Lea T. Grinberg","orcid":"0000-0002-6809-0618","position":12,"is_corresponding":false},{"id":226634,"name":"Cláudia Kimie Suemoto","orcid":"0000-0002-5942-4778","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:54:03.053965Z","pmid":"41268805","pmcid":"PMC12635860","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}