{"doi":"10.1002/alz.70882","title":"Amyloid beta binding partners in the brain tissue of older adults","abstract":"INTRODUCTION: The mechanism linking extracellular amyloid beta (Aβ) with intraneuronal tau tangles, pathological hallmarks of Alzheimer's disease (AD), is not understood; it was tested in the current study through Aβ binding partners. METHODS: Data were from decedents of community-based clinical-pathological studies. Of 52 Aβ binding partners, suggested by non-human studies, levels of 34 together with total Aβ protein were quantified in the dorsolateral prefrontal cortex. Post mortem pathological assessment immunohistochemically quantified Aβ load and tau tangle density. RESULTS: The strongest mediations between Aβ and tau tangles were observed for Ras-related C3 botulinum toxin substrate 1 (RAC1) and sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3), which collectively mediated 10.1% of the association between Aβ and tau tangles. In contrast, Aβ mediated >70% of the associations of matrix proteins with tau tangles. DISCUSSION: Identification of Aβ binding partners that mediate the association between Aβ and tau tangles may provide new targets for AD treatment. HIGHLIGHTS: RAC1 linked Aβ with tau tangles. ATP1A3 linked Aβ with tau. RAC1 and ATP1A3 collectively mediated 10.1% of the association between Aβ and tau. Aβ mediated >70% of the associations of matrix proteins, such as APOE, with tau.","journal":"Alzheimer s & Dementia","year":2025,"id":529301,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5101,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":392045,"name":"Lei Yu","orcid":"0000-0003-1093-9188","position":1,"is_corresponding":false},{"id":861528,"name":"Yanling Wang","orcid":"0000-0001-6645-9883","position":2,"is_corresponding":false},{"id":742374,"name":"Jingyun Yang","orcid":"0000-0002-2289-2666","position":3,"is_corresponding":false},{"id":554051,"name":"Ricardo A. Vialle","orcid":"0000-0003-3311-4197","position":4,"is_corresponding":false},{"id":550555,"name":"Kátia de Paiva Lopes","orcid":"0000-0002-0240-0126","position":5,"is_corresponding":false},{"id":78444,"name":"Shinya Tasaki","orcid":"0000-0003-3656-7394","position":6,"is_corresponding":false},{"id":63306,"name":"Tracy L. Young‐Pearse","orcid":"0000-0001-7846-1542","position":7,"is_corresponding":false},{"id":771,"name":"Philip L. De Jager","orcid":"0000-0002-8057-2505","position":8,"is_corresponding":false},{"id":60409,"name":"Vladislav Petyuk","orcid":"0000-0003-4076-151X","position":9,"is_corresponding":false},{"id":7426,"name":"Julie A. Schneider","orcid":"0000-0002-9482-1752","position":10,"is_corresponding":false},{"id":21539,"name":"Nicholas T. Seyfried","orcid":"0000-0002-4507-624X","position":11,"is_corresponding":false},{"id":322308,"name":"David Bennett","orcid":"0000-0001-5354-152X","position":12,"is_corresponding":false},{"id":450779,"name":"Shahram Oveisgharan","orcid":"0000-0001-6841-4830","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41216806","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}