{"doi":"10.1002/alz.70692","title":"Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study","abstract":"INTRODUCTION: This study investigates the impact of cardiometabolic conditions, including type 2 diabetes, hyperlipidemia, hypertension, and obesity, on the progression of mild cognitive impairment (MCI) to dementia. METHODS: The cohort included adults ≥ 50 years old with MCI and a cardiometabolic condition identified through electronic health records. Propensity score matching was applied to control for confounders, and Kaplan-Meier analysis was used to assess time-to-event outcomes. RESULTS: During a 7-year median follow-up, type 2 diabetes was associated with the highest risk of all-cause dementia (hazard ratio [HR] 1.18, 95% confidence interval [CI]: 1.06 to 1.31), followed by hypertension and hyperlipidemia. For vascular dementia, type 2 diabetes conferred the greatest risk (HR 1.33, 95% CI: 1.07 to 1.64). Hyperlipidemia was the sole cardiometabolic factor significantly associated with Alzheimer's disease (AD) risk (HR 1.21, 95% CI: 1.11 to 1.32). CONCLUSIONS: Hyperlipidemia is primarily associated with AD dementia risk, while type 2 diabetes is the major contributor to vascular dementia and all-cause risk in individuals with MCI. HIGHLIGHTS: Type 2 diabetes, hypertension, and hyperlipidemia are associated with a high risk of developing all-cause dementia in participants already diagnosed with mild cognitive impairment (MCI). Type 2 diabetes was shown to pose a high risk for the progression from MCI to vascular dementia. Hyperlipidemia was associated with Alzheimer's disease progression in individuals with MCI.","journal":"Alzheimer s & Dementia","year":2025,"id":534711,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1206070,"name":"Michail Kokkorakis","orcid":"0000-0002-0027-5659","position":1,"is_corresponding":false},{"id":1417841,"name":"Christos Asvestis","orcid":"0009-0003-5565-030X","position":2,"is_corresponding":false},{"id":1418373,"name":"Ilias Papadimopoulos","orcid":null,"position":3,"is_corresponding":false},{"id":1418374,"name":"Shrihari Nagarajan","orcid":null,"position":4,"is_corresponding":false},{"id":594692,"name":"Konrad Talbot","orcid":"0000-0003-4549-0835","position":5,"is_corresponding":false},{"id":1163295,"name":"Lu Li","orcid":"0000-0002-2891-6067","position":6,"is_corresponding":false},{"id":14813,"name":"Yong Chen","orcid":"0000-0003-0835-0788","position":7,"is_corresponding":false},{"id":230030,"name":"Ilya M. Nasrallah","orcid":"0000-0003-2346-7562","position":8,"is_corresponding":false},{"id":34917,"name":"Junhao Wen","orcid":"0000-0003-2077-3070","position":9,"is_corresponding":false},{"id":34918,"name":"Christos Davatzikos","orcid":"0000-0002-1025-8561","position":10,"is_corresponding":false},{"id":1360848,"name":"Filippos Anagnostakis","orcid":"0000-0001-7374-8798","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:51:52.019261Z","pmid":"40951936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}