{"doi":"10.1002/alz.70551","title":"Factors associated with age at tau pathology onset and time from tau onset to dementia in Alzheimer's disease","abstract":"INTRODUCTION: Elevated tau (T+) is temporally proximal to dementia onset but less is known about factors influencing T+ onset age and time to dementia after T+ in Alzheimer's disease (AD). We used sampled iterative local approximation (SILA) estimated T+ onset age (ETOA) to investigate factors associated with T+ age and time from T+ to dementia onset in the Alzheimer's Disease Neuroimaging Initiative. METHODS: F-Florbetaben positron emission tomography and Cox proportional hazards and accelerated failure time models, we analyzed apolipoprotein E (APOE), sex, amyloid burden, age, educational attainment, and literacy associations with ETOA and time from T+ to dementia. RESULTS: Higher amyloid, APOE-ε4, lower education, and lower literacy associated with younger ETOA. Older ETOA and higher amyloid associated with shorter time from T+ to dementia. DISCUSSION: This work highlights the prognostic value of ETOA and the need to better characterize factors contributing to ETOA and dementia onset in AD. HIGHLIGHTS: F-Flortaucipir data, to estimate individuals' age of tau pathology onset (T+) and time from T+ onset to dementia. Higher amyloid, apolipoprotein E ε4, lower education, and lower literacy associated with younger estimated T+ onset age. Older T+ onset age and higher amyloid associated with shorter time from T+ to dementia. Only one individual was observed to remain dementia free 14 years after T+ onset. This work highlights the prognostic value of T+ onset age and the need to better characterize factors contributing to T+ onset age and dementia onset in Alzheimer's disease.","journal":"Alzheimer s & Dementia","year":2025,"id":514010,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9275,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1310418,"name":"Jordan P Teague","orcid":"0000-0001-6688-6949","position":1,"is_corresponding":false},{"id":289692,"name":"Karly Alex Cody","orcid":"0000-0001-5996-2560","position":2,"is_corresponding":false},{"id":265268,"name":"Yuetiva Deming","orcid":null,"position":3,"is_corresponding":false},{"id":1310806,"name":"Elena Ruiz De Chavez","orcid":null,"position":4,"is_corresponding":false},{"id":1376537,"name":"Jacob Morse","orcid":null,"position":5,"is_corresponding":false},{"id":289693,"name":"Nathaniel A. Chin","orcid":"0000-0001-8008-9356","position":6,"is_corresponding":false},{"id":261840,"name":"Corinne D. Engelman","orcid":"0000-0003-4750-5607","position":7,"is_corresponding":false},{"id":395992,"name":"Richard J. Chappell","orcid":"0000-0002-3891-0881","position":8,"is_corresponding":false},{"id":1160541,"name":"Rebecca E. Langhough","orcid":null,"position":9,"is_corresponding":false},{"id":500811,"name":"Carey E. Gleason","orcid":"0000-0001-6210-4671","position":10,"is_corresponding":false},{"id":289690,"name":"Lindsay R. Clark","orcid":"0000-0003-4837-7627","position":11,"is_corresponding":false},{"id":493819,"name":"Megan Zuelsdorff","orcid":"0000-0002-9632-475X","position":12,"is_corresponding":false},{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":13,"is_corresponding":false},{"id":300139,"name":"for the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":14,"is_corresponding":false},{"id":860137,"name":"Margo B. Heston","orcid":"0000-0002-0980-2275","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T02:48:23.284782Z","pmid":"40859634","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}