{"doi":"10.1002/alz.70485","title":"Language impairment is associated with faster progression in progressive supranuclear palsy‐Richardson syndrome","abstract":"INTRODUCTION: Cognitive impairment is common but often overlooked due to motor symptoms in progressive supranuclear palsy-Richardson syndrome (PSP-RS). This study investigates whether cognitive deficits predict disease progression in PSP-RS. METHODS: A total of 146 PSP-RS from the Tilavonemab trial were evaluated at baseline and over 52 weeks using the PSP-Rating Scale (PSPRS), the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Unified Parkinson's Disease Rating Scale Part-II (UPDRS-II). Multiple linear regression analyses were performed between the RBANS, UPDRS-II, and the PSPRS change. Clinical scores, gray matter volumes, and neurofilament-light chain (NfL) were compared using analyses of covariance (ANCOVAs) and linear mixed models between language score-groups. RESULTS: Lower RBANS-language at baseline predicted greater PSPRS worsening over time. The low language-score group showed poorer cognitive performance, elevated NfL, and reduced gray matter volume in language-related areas. DISCUSSION: Speech/language deficits predict worse prognosis in PSP-RS, emphasizing the value of including language scores in clinical trials. HIGHLIGHTS: Speech and language deficits predict a worse prognosis in progressive supranuclear palsy-Richardson syndrome (PSP-RS). Lower language scores are associated with worse cognitive performance over time. Lower language scores related to higher neurofilament-light chain (NfL) at baseline. The low language-score group presented greater atrophy in language-related brain areas. Stratifying PSP-RS cases using language scores may improve clinical trials.","journal":"Alzheimer s & Dementia","year":2025,"id":532689,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9641,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1311322,"name":"Juan‐Camilo Vargas‐González","orcid":"0000-0002-1719-2200","position":1,"is_corresponding":false},{"id":1410762,"name":"Mohsen Hadian","orcid":"0000-0002-6789-0517","position":2,"is_corresponding":false},{"id":440109,"name":"Ece Bayram","orcid":"0000-0002-6875-4242","position":3,"is_corresponding":false},{"id":850090,"name":"Federico Rodríguez‐Porcel","orcid":"0000-0002-7492-5095","position":4,"is_corresponding":false},{"id":900877,"name":"Blas Couto","orcid":"0000-0002-3512-7488","position":5,"is_corresponding":false},{"id":1119975,"name":"Jay M. 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McFarland","orcid":"0000-0002-8699-8857","position":11,"is_corresponding":false},{"id":491843,"name":"Tao Xie","orcid":"0000-0001-9551-6613","position":12,"is_corresponding":false},{"id":661647,"name":"Matthew Swan","orcid":"0000-0003-0516-4680","position":13,"is_corresponding":false},{"id":1053920,"name":"Kyurim Kang","orcid":"0000-0001-8061-4456","position":14,"is_corresponding":false},{"id":307559,"name":"Douglas Gunzler","orcid":"0000-0003-3786-8578","position":15,"is_corresponding":false},{"id":500722,"name":"Anne‐Marie Wills","orcid":"0000-0002-0901-4711","position":16,"is_corresponding":false},{"id":847334,"name":"Adam Boxer","orcid":null,"position":17,"is_corresponding":false},{"id":230246,"name":"Irene Litvan","orcid":"0000-0002-3485-3445","position":18,"is_corresponding":false},{"id":17424,"name":"Anthony E. Lang","orcid":"0000-0003-1229-3667","position":19,"is_corresponding":false},{"id":253935,"name":"Maria Carmela Tartaglia","orcid":"0000-0002-5944-8497","position":20,"is_corresponding":false},{"id":670769,"name":"Indira García‐Cordero","orcid":"0000-0001-9739-5018","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:51:27.893975Z","pmid":"40684253","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}