{"doi":"10.1002/alz.70463","title":"Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease","abstract":"INTRODUCTION: Given the predominance of imaging and plasma biomarkers in Alzheimer's disease observational studies and clinical trials, it is critical to understand the differences between these biomarkers across racialized groups. METHODS: A total of 260 older adults without dementia racialized as Black and/or African American (AA) and non-Hispanic white (NHW), ranging in age from 50 to 90 years (68.8 ± 9.1 years), were evaluated for differences in plasma amyloid-β (Aβ) 42/Aβ40, p-tau181, p-tau217, p-tau231, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) as well as Aβ positron emission tomography (PET) and magnetic resonance (MR) imaging-derived cortical thickness using Mann-Whitney U tests and analysis of covariance (ANCOVA). RESULTS: [C]-Pittsburgh Compound B (PiB) standardized uptake value ratio (SUVR), cortical thickness values, p-tau181, and p-tau231 values (p < 0.05). DISCUSSION: Racialization should be given more consideration in AD clinical research, particularly when biomarker results are used for inclusion or exclusion criteria for clinical trials and qualification in clinical practice. HIGHLIGHTS: [C]-Pittsburgh compound B (PiB) standardized uptake value ratio (SUVR), cortical thickness, p-tau181, and p-tau231 differed between groups Differences were unaffected by age, sex, apolipoprotein E *4 (APOE*4), education, and Mini-Mental State Examination (MMSE) score Racialization needs more consideration in Alzheimer's disease clinical research Additional work is needed to understand the sources of biomarker differences.","journal":"Alzheimer s & Dementia","year":2025,"id":521593,"datarank":0.27603768709378795,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.007273766709579673,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.007273766709579673,"corpus_percentile":42.80188752224027,"corpus_rank":7395,"citation_count":5,"citer_count":4,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":518875,"name":"Xuemei Zeng","orcid":"0000-0003-4885-4788","position":1,"is_corresponding":false},{"id":1391927,"name":"Lilcelia A. 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Ikonomović","orcid":"0000-0002-8745-3293","position":9,"is_corresponding":false},{"id":98,"name":"Julia Kofler","orcid":"0000-0003-4298-7328","position":10,"is_corresponding":false},{"id":1315602,"name":"Cristy Matan","orcid":null,"position":11,"is_corresponding":false},{"id":272069,"name":"Tharick A. Pascoal","orcid":"0000-0001-9057-8014","position":12,"is_corresponding":false},{"id":457624,"name":"Howard Aizenstein","orcid":"0000-0003-4897-6582","position":13,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":14,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":15,"is_corresponding":false},{"id":245369,"name":"Oscar L. López","orcid":"0000-0002-8546-8256","position":16,"is_corresponding":false},{"id":236168,"name":"Victor L. Villemagne","orcid":"0000-0002-5832-9875","position":17,"is_corresponding":false},{"id":241105,"name":"Thomas K. 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