{"doi":"10.1002/alz.70400","title":"Impact of Alzheimer's disease on sleep in adults with Down syndrome","abstract":"INTRODUCTION: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum. METHODS: We studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography. RESULTS: Adults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders. CONCLUSIONS: In DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression. HIGHLIGHTS: Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.","journal":"Alzheimer s & Dementia","year":2025,"id":523782,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.716,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267968,"name":"Lídia Vaqué‐Alcázar","orcid":"0000-0002-6776-6559","position":1,"is_corresponding":false},{"id":854801,"name":"Nuole Zhu","orcid":"0000-0002-0015-9455","position":2,"is_corresponding":false},{"id":232594,"name":"Bessy Benejam","orcid":"0000-0002-6789-8615","position":3,"is_corresponding":false},{"id":854802,"name":"Javier Arranz","orcid":"0000-0003-0891-1215","position":4,"is_corresponding":false},{"id":1244953,"name":"Lucía Maure-Blesa","orcid":"0000-0001-5643-7971","position":5,"is_corresponding":false},{"id":232595,"name":"Laura Videla","orcid":"0000-0002-9748-8465","position":6,"is_corresponding":false},{"id":232593,"name":"María Carmona‐Iragui","orcid":"0000-0001-6914-2339","position":7,"is_corresponding":false},{"id":232596,"name":"Isabel Barroeta","orcid":"0000-0003-2764-7923","position":8,"is_corresponding":false},{"id":634168,"name":"Anne‐Sophie Rebillat","orcid":"0000-0003-1995-9177","position":9,"is_corresponding":false},{"id":1161123,"name":"Íñigo Rodríguez‐Baz","orcid":"0000-0003-3039-9115","position":10,"is_corresponding":false},{"id":304542,"name":"Alexandre Bejanin","orcid":"0000-0002-9958-0951","position":11,"is_corresponding":false},{"id":1224913,"name":"José Enrique Arriola‐Infante","orcid":"0000-0002-3298-4601","position":12,"is_corresponding":false},{"id":1396686,"name":"Ana Carolina Bueno","orcid":"0000-0001-9043-9831","position":13,"is_corresponding":false},{"id":1396687,"name":"Susana Fernández","orcid":"0000-0003-4154-682X","position":14,"is_corresponding":false},{"id":867468,"name":"Laia Ribas","orcid":"0000-0001-5538-6236","position":15,"is_corresponding":false},{"id":1224912,"name":"Sára E. Zsadanyi","orcid":"0000-0002-2033-5989","position":16,"is_corresponding":false},{"id":1224911,"name":"Alejandra O. Morcillo‐Nieto","orcid":"0000-0003-2202-3521","position":17,"is_corresponding":false},{"id":232612,"name":"Daniel Alcolea","orcid":"0000-0002-3819-3245","position":18,"is_corresponding":false},{"id":808114,"name":"Christos Panagiotis Lisgaras","orcid":"0000-0003-3712-5993","position":19,"is_corresponding":false},{"id":686641,"name":"Esther Blessing","orcid":"0000-0002-7961-8844","position":20,"is_corresponding":false},{"id":232608,"name":"Ricardo S. 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