{"doi":"10.1002/alz.70160","title":"Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study","abstract":"INTRODUCTION: We investigated whether depression modified the associations between sleep duration and cognitive performance. METHODS: We examined the associations between sleep duration and cognition in 1853 dementia-and-stroke-free participants (mean age 49.8 years, [range 27-85]; 42.7% male). Participants were categorized into four groups: no depressive symptoms, no antidepressants; depressive symptoms without antidepressant use; antidepressant use without depressive symptoms; and depressive symptoms and antidepressant use. RESULTS: Long sleep was associated with reduced overall cognitive function (β ± standard error = -0.25 ± 0.07, p < 0.001), with strongest effects in those with depressive symptoms using (-0.74 ± 0.30, p = 0.017) and not using antidepressants (-0.60 ± 0.26, p = 0.024). Weaker but significant effects were observed in those without depressive symptoms (-0.18 ± 0.09, p = 0.044). No significant associations were observed in participants using antidepressants without depressive symptoms. DISCUSSION: Associations between sleep duration and cognitive performance are strongest in individuals with depressive symptoms, regardless of antidepressant use. Future research should elucidate underlying mechanisms and temporal relationships. HIGHLIGHTS: Sleeping ≥ 9 hours/night was associated with worse cognitive performance. This association was stronger among those with depression. Long sleepers were more likely to report symptoms of depression. Sleep may be a modifiable risk for cognitive decline in people with depression.","journal":"Alzheimer s & Dementia","year":2025,"id":513300,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.916,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1238994,"name":"Rebecca Bernal","orcid":null,"position":1,"is_corresponding":false},{"id":489725,"name":"Andrée‐Ann Baril","orcid":null,"position":2,"is_corresponding":false},{"id":1374981,"name":"Joy Zeynoun","orcid":null,"position":3,"is_corresponding":false},{"id":871818,"name":"Crystal Wiedner","orcid":null,"position":4,"is_corresponding":false},{"id":1374338,"name":"Carlos Gaona","orcid":"0009-0000-9425-8907","position":5,"is_corresponding":false},{"id":216030,"name":"Alexa Beiser","orcid":null,"position":6,"is_corresponding":false},{"id":3176,"name":"Antônio Lúcio Teixeira","orcid":"0000-0002-9621-5422","position":7,"is_corresponding":false},{"id":1367877,"name":"Arash Salardini","orcid":"0000-0003-0193-6217","position":8,"is_corresponding":false},{"id":350988,"name":"Matthew P. Pase","orcid":"0000-0002-4143-8485","position":9,"is_corresponding":false},{"id":276095,"name":"Jayandra J. Himali","orcid":null,"position":10,"is_corresponding":false},{"id":17639,"name":"Sudha Seshadri","orcid":"0000-0001-6135-2622","position":11,"is_corresponding":false},{"id":1374337,"name":"Vanessa M. Young","orcid":"0000-0003-4633-5052","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T02:48:17.908238Z","pmid":"40257009","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}